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dc.contributor.authorvan den Berg, Sara P H
dc.contributor.authorPardieck, Iris N
dc.contributor.authorLanfermeijer, Josien
dc.contributor.authorSauce, Delphine
dc.contributor.authorKlenerman, Paul
dc.contributor.authorvan Baarle, Debbie
dc.contributor.authorArens, Ramon
dc.date.accessioned2019-04-26T08:36:37Z
dc.date.available2019-04-26T08:36:37Z
dc.date.issued2019-04-13
dc.identifier.issn1432-1831
dc.identifier.pmid30989333
dc.identifier.doi10.1007/s00430-019-00608-7
dc.identifier.urihttp://hdl.handle.net/10029/623049
dc.description.abstractUpon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced differentiation state. Here, we will review this "special" differentiation status by discussing the cellular phenotype based on the expression of CD45 isoforms, costimulatory, inhibitory and natural killer receptors, adhesion and lymphocyte homing molecules, transcription factors, cytokines and cytotoxic molecules. In addition, we focus on whether the differentiation state of CMV-specific CD8 T cells is unique in comparison with other chronic viruses and we will discuss the possible impact of factors such as antigen exposure and aging on the advanced differentiation status of CMV-specific CD8 T cells.en_US
dc.language.isoenen_US
dc.subjectCD8 T cellen_US
dc.subjectCytomegalovirusen_US
dc.subjectDifferentiationen_US
dc.subjectPhenotypeen_US
dc.titleThe hallmarks of CMV-specific CD8 T-cell differentiation.en_US
dc.typeArticleen_US
dc.identifier.journalMed Microbiol Immunol 2019; 208(3-4):365-73en_US
dc.source.journaltitleMedical microbiology and immunology


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