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dc.contributor.authorJongbloed, F
dc.contributor.authorMeijers, R W J
dc.contributor.authorIJzermans, J N M
dc.contributor.authorKlaassen, R A
dc.contributor.authorDollé, M E T
dc.contributor.authorvan den Berg, S
dc.contributor.authorBetjes, M G H
dc.contributor.authorde Bruin, R W F
dc.contributor.authorvan der Harst, E
dc.contributor.authorLitjens, N H R
dc.date.accessioned2019-04-26T08:39:46Z
dc.date.available2019-04-26T08:39:46Z
dc.date.issued2019-04-12
dc.identifier.issn1476-5497
dc.identifier.pmid30979972
dc.identifier.doi10.1038/s41366-019-0351-y
dc.identifier.urihttp://hdl.handle.net/10029/623051
dc.description.abstractObesity adversely affects health and is associated with subclinical systemic inflammation and features of accelerated aging, including the T-cell immune system. The presence of metabolic syndrome (MetS) may accelerate, while bariatric surgery might reverse these phenomena. To examine the effects of MetS and bariatric surgery on T-cell aging, we measured relative telomere length (RTL) and T-cell differentiation status in obese patients before and after bariatric surgery. WHO II/III classified obese patients scheduled for bariatric surgery were included: 41 without MetS and 67 with MetS. RTL and T-cell differentiation status were measured in circulating CD4 Thymic output, represented by numbers of CD31-expressing naive T cells, showed an age-related decline in patients with MetS. MetS significantly enhanced CD8 In obese patients, MetS results in attrition of RTL and accelerated T-cell differentiation. Bariatric surgery temporarily reverses these effects. These data suggest that MetS is a risk factor for accelerated aging of T cells and that MetS should be a more prominent factor in the decision making for eligibility for bariatric surgery.en_US
dc.language.isoenen_US
dc.titleEffects of bariatric surgery on telomere length and T-cell aging.en_US
dc.typeArticleen_US
dc.identifier.journalInt J Obes 2019; advance online publication (ahead of print)en_US
dc.source.journaltitleInternational journal of obesity (2005)


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