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dc.contributor.authorO'Connor, Daniel
dc.contributor.authorPng, Eileen
dc.contributor.authorKhor, Chiea Chuen
dc.contributor.authorSnape, Matthew D
dc.contributor.authorHill, Adrian V S
dc.contributor.authorvan der Klis, Fiona
dc.contributor.authorHoggart, Clive
dc.contributor.authorLevin, Michael
dc.contributor.authorHibberd, Martin L
dc.contributor.authorPollard, Andrew J
dc.date.accessioned2019-07-30T12:41:45Z
dc.date.available2019-07-30T12:41:45Z
dc.date.issued2019-06-11
dc.identifier.issn2211-1247
dc.identifier.pmid31189108
dc.identifier.doi10.1016/j.celrep.2019.05.053
dc.identifier.urihttp://hdl.handle.net/10029/623203
dc.description.abstractVaccines have revolutionized public health, preventing millions of deaths each year, particularly in childhood. Yet, there is considerable variability in the magnitude and persistence of vaccine-induced immunity. Maintenance of specific antibody is essential for continuity of vaccine-induced serological protection. We conducted a genome-wide association study into the persistence of immunity to three childhood vaccines: capsular group C meningococcal (MenC), Haemophilus influenzae type b, and tetanus toxoid (TT) vaccines. We detail associations between variants in a locus containing a family of signal-regulatory proteins and the persistence MenC immunity. We postulate a regulatory role for the lead SNP, with supporting epigenetic and expression quantitative trait loci data. Furthermore, we define associations between SNPs in the human leukocyte antigen (HLA) locus and the persistence of TT-specific immunity. Moreover, we describe four classical HLA alleles, HLA DRB1∗0301, HLA DQB1∗0201, HLA DQB1∗0602, and HLA DRB1∗1501, associated with TT-specific immunity, independent of the lead SNP association.en_US
dc.language.isoenen_US
dc.subjectGWASen_US
dc.subjectHLAen_US
dc.subjectSIRPGen_US
dc.subjectmeningococcal diseaseen_US
dc.subjectpersistence of immunityen_US
dc.subjectvaccine-induced immunityen_US
dc.titleCommon Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization.en_US
dc.typeArticleen_US
dc.identifier.journalCell Rep 2019; 27(11):3241-53.e4en_US
dc.source.journaltitleCell reports


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