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dc.contributor.authorvan Paassen, Judith
dc.contributor.authorvan Dissel, Jaap T
dc.contributor.authorHiemstra, Pieter S
dc.contributor.authorZwaginga, Jaap Jan
dc.contributor.authorCobbaert, Christa M
dc.contributor.authorJuffermans, Nicole P
dc.contributor.authorde Wilde, Rob B
dc.contributor.authorStijnen, Theo
dc.contributor.authorde Jonge, Evert
dc.contributor.authorKlautz, Robert J
dc.contributor.authorArbous, M Sesmu
dc.date.accessioned2019-10-03T11:18:50Z
dc.date.available2019-10-03T11:18:50Z
dc.date.issued2019-09-01
dc.identifier.issn1752-0371
dc.identifier.pmid31544475
dc.identifier.doi10.2217/bmm-2019-0028
dc.identifier.urihttp://hdl.handle.net/10029/623259
dc.description.abstractAim: Biomarkers of acute respiratory distress syndrome (ARDS) after cardiac-surgery may help risk-stratification and management. Preoperative single-value proADM increases predictive capacity of scoring-system EuroSCORE. To include the impact of surgery, we aim to assess the predictive value of the perioperative proADM-change on development of ARDS in 40 cardiac-surgery patients. Materials & methods: ProADM was measured in nine sequential blood samples. The Berlin definition of ARDS was used. For data-analyses, a multivariate model of EuroSCORE and perioperative proADM-change, linear mixed models and logistic regression were used. Results: Perioperative proADM-change was associated with ARDS after cardiac-surgery, and it was superior to EuroSCORE. A perioperative proADM-change >1.5 nmol/l could predict ARDS. Conclusion: Predicting post-surgery ARDS with perioperative proADM-change enables clinicians to intensify lung-protective interventions and individualized fluid therapy to minimize secondary injury.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectARDSen_US
dc.subjectProADMen_US
dc.subjectbiomarkeren_US
dc.subjectcardiac surgeryen_US
dc.subjectclinical scoring systemen_US
dc.subjectintensive careen_US
dc.subjectoutcomeen_US
dc.subjectpredictionen_US
dc.titlePerioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study.en_US
dc.typeArticleen_US
dc.identifier.journalBiomark Med 2019; 13(13):1081-91en_US
dc.source.journaltitleBiomarkers in medicine


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