Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study.
dc.contributor.author | van Paassen, Judith | |
dc.contributor.author | van Dissel, Jaap T | |
dc.contributor.author | Hiemstra, Pieter S | |
dc.contributor.author | Zwaginga, Jaap Jan | |
dc.contributor.author | Cobbaert, Christa M | |
dc.contributor.author | Juffermans, Nicole P | |
dc.contributor.author | de Wilde, Rob B | |
dc.contributor.author | Stijnen, Theo | |
dc.contributor.author | de Jonge, Evert | |
dc.contributor.author | Klautz, Robert J | |
dc.contributor.author | Arbous, M Sesmu | |
dc.date.accessioned | 2019-10-03T11:18:50Z | |
dc.date.available | 2019-10-03T11:18:50Z | |
dc.date.issued | 2019-09-01 | |
dc.identifier.issn | 1752-0371 | |
dc.identifier.pmid | 31544475 | |
dc.identifier.doi | 10.2217/bmm-2019-0028 | |
dc.identifier.uri | http://hdl.handle.net/10029/623259 | |
dc.description.abstract | Aim: Biomarkers of acute respiratory distress syndrome (ARDS) after cardiac-surgery may help risk-stratification and management. Preoperative single-value proADM increases predictive capacity of scoring-system EuroSCORE. To include the impact of surgery, we aim to assess the predictive value of the perioperative proADM-change on development of ARDS in 40 cardiac-surgery patients. Materials & methods: ProADM was measured in nine sequential blood samples. The Berlin definition of ARDS was used. For data-analyses, a multivariate model of EuroSCORE and perioperative proADM-change, linear mixed models and logistic regression were used. Results: Perioperative proADM-change was associated with ARDS after cardiac-surgery, and it was superior to EuroSCORE. A perioperative proADM-change >1.5 nmol/l could predict ARDS. Conclusion: Predicting post-surgery ARDS with perioperative proADM-change enables clinicians to intensify lung-protective interventions and individualized fluid therapy to minimize secondary injury. | en_US |
dc.language.iso | en | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | ARDS | en_US |
dc.subject | ProADM | en_US |
dc.subject | biomarker | en_US |
dc.subject | cardiac surgery | en_US |
dc.subject | clinical scoring system | en_US |
dc.subject | intensive care | en_US |
dc.subject | outcome | en_US |
dc.subject | prediction | en_US |
dc.title | Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study. | en_US |
dc.type | Article | en_US |
dc.identifier.journal | Biomark Med 2019; 13(13):1081-91 | en_US |
dc.source.journaltitle | Biomarkers in medicine |