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dc.contributor.authorHoenderboom, Bernice M
dc.contributor.authorvan Willige, Michelle E
dc.contributor.authorLand, Jolande A
dc.contributor.authorPleijster, Jolein
dc.contributor.authorGötz, Hannelore M
dc.contributor.authorvan Bergen, Jan E A M
dc.contributor.authorDukers-Muijrers, Nicole H T M
dc.contributor.authorHoebe, Christian J P A
dc.contributor.authorvan Benthem, Birgit H B
dc.contributor.authorMorré, Servaas A
dc.date.accessioned2019-10-21T20:38:39Z
dc.date.available2019-10-21T20:38:39Z
dc.date.issued2019-10-11
dc.identifier.issn2076-2607
dc.identifier.pmid31614620
dc.identifier.doi10.3390/microorganisms7100442
dc.identifier.urihttp://hdl.handle.net/10029/623399
dc.description.abstractThe asymptomatic course of Chlamydia trachomatis (CT) infections can result in underestimated CT lifetime prevalence. Antibody testing might improve this estimate. We assessed CT antibody positivity and predictive factors thereof in the Netherlands Chlamydia Cohort Study. Women who had ≥1 CT Nucleic Acid Amplification Test (NAAT) in the study (2008-2011) and who provided self-reported information on NAATs were tested for CT major outer membrane protein specific IgG in serum (2016). CT antibody positivity was assessed and predictive factors were identified using multivariable logistic regressions, separately for CT-positive women (≥1 positive NAAT or ≥1 self-reported positive CT test) and CT-negative women (negative by study NAAT and self-report). Of the 3,613 women studied, 833 (23.1%) were CT -positive. Among the CT-negative women, 208 (7.5%, 95%CI 6.5-8.5) tested positive for CT antibodies. This increased CT lifetime prevalence with 5.8% (95%CI 5.0-6.5). Among women with a CT-positive history, 338 (40.6%, 95%CI 38.5-44.1) tested positive. Predictive factors for antibody positivity related to lower social economic status, sexual risk behavior, multiple infections, higher body mass index, and non-smoking. CT antibody testing significantly increased the lifetime prevalence. Combining NAAT outcomes, self-reported positive tests, and antibody testing reduced misclassification in CT prevalence estimates.en_US
dc.language.isoenen_US
dc.subjectChlamydia trachomatisen_US
dc.subjectantibodiesen_US
dc.subjectantibody testingen_US
dc.subjectchlamydia IgGen_US
dc.subjectprevalenceen_US
dc.titleAntibody Testing in Estimating Past Exposure to C in the Netherlands Chlamydia Cohort Study.en_US
dc.typeArticleen_US
dc.identifier.journalMicroorganisms 2019; 7(10):pii.e442en_US
dc.source.journaltitleMicroorganisms


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