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dc.contributor.authorvan Baal, Jantine W P M
dc.contributor.authorRoszek, Boris
dc.contributor.authorvan Elk, Merel
dc.contributor.authorGeertsma, Robert E
dc.date.accessioned2019-10-23T18:24:11Z
dc.date.available2019-10-23T18:24:11Z
dc.date.issued2019-10-01
dc.identifier.issn1745-2422
dc.identifier.pmid31564181
dc.identifier.doi10.1080/17434440.2019.1674138
dc.identifier.urihttp://hdl.handle.net/10029/623427
dc.description.abstractIntroduction: Patients with severe aortic stenosis and regurgitation who are inoperable or at high-risk for surgery can be treated with transcatheter aortic valve replacement (TAVR). The aim of this study was to provide a comprehensive overview of the literature of TAVR and reported clinical and performance outcomes. Areas covered: A total of 16 devices, described in 204 articles describing clinical and performance outcomes, were included. The most frequently observed outcome was 30-day mortality, ranging between 0-23%. Other commonly reported clinical outcomes were 30-day stroke, ranging between 0-14.3% and pacemaker implantation, ranging from 0-44.9%. The most common valve performance outcome was aortic valve regurgitation, however, mostly reported at 7 days follow-up. Next to a follow-up period of 30 days, numerous articles reported outcomes at 6 months and 1 year. The numbers of articles describing outcomes with a longer follow-up as well as including intermediate and low-risk patients were limited. Expert commentary: This literature review provided a clear overview of the reported clinical and performance outcomes of TAVR devices. Despite the frequently used VARC-2 definitions, we identified a huge variation across studies. Future studies using standardized definitions of study set-ups and outcomes are essential and might lead to better insights of TAVR.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTranscatheter aortic valve implantation (TAVI)en_US
dc.subjectVARCen_US
dc.subjectclinical dataen_US
dc.subjecttranscatheter aortic valve replacement (TAVR)en_US
dc.subjecttranscatheter heart valve (THV)en_US
dc.titleTranscatheter aortic valve replacement: clinical safety and performance data.en_US
dc.typeArticleen_US
dc.identifier.journalExpert Rev Med Devices 2019; 16(10):899-911en_US
dc.source.journaltitleExpert review of medical devices


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