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dc.contributor.authorZhang, Li
dc.contributor.authorvan der Hoek, Wim
dc.contributor.authorKrafft, Thomas
dc.contributor.authorPilot, Eva
dc.contributor.authorAsten, Liselotte van
dc.contributor.authorLin, Ge
dc.contributor.authorWu, Shuangsheng
dc.contributor.authorDuan, Wei
dc.contributor.authorYang, Peng
dc.contributor.authorWang, Quanyi
dc.date.accessioned2019-10-23T18:41:14Z
dc.date.available2019-10-23T18:41:14Z
dc.date.issued2019-10-09
dc.identifier.issn2164-554X
dc.identifier.pmid31596661
dc.identifier.doi10.1080/21645515.2019.1677438
dc.identifier.urihttp://hdl.handle.net/10029/623433
dc.description.abstractBackground: Since 2007, trivalent inactivated influenza vaccine (TIV) has been provided free-of-charge to primary, middle school and high school students in Beijing. However, there have been few school-based studies on influenza vaccine effectiveness (VE). In this report we estimated influenza VE against laboratory-confirmed influenza illness among school children in Beijing, China during the 2016-2017 influenza season. Methods: The VE of 2016-2017 TIV against laboratory-confirmed influenza virus infection among school-age children was assessed through a case-control design. Conditional logistic regression was conducted on matched case-control sets to estimate VE. The effect of prior vaccination on current VE was also examined. Results: All 176 samples tested positive for influenza A virus with the positive rate of 55.5%. The average coverage rate of 2016-2017 TIV among students across the 37 schools was 30.6%. The fully adjusted VE of 2016-2017 TIV against laboratory-confirmed influenza was 69% (95% CI: 51 to 81): 60% (95% CI: -15 to 86) for influenza A(H1N1)pdm09 and 73% (95% CI: 52 to 84) for influenza A(H3N2). The overall VE for receipt of 2015-2016 vaccination only, 2016-2017 vaccination only, and vaccinations in both seasons was 46% (95% CI: -5 to 72), 77% (95% CI: 58 to 87), and 57% (95%CI: 17 to 78), respectively. Conclusions: Our study during school outbreaks found that VE of 2016-2017 TIV was moderate against influenza A(H3N2) as well as A(H1N1)pdm09viruses.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChildrenen_US
dc.subjectChinaen_US
dc.subjectInfluenzaen_US
dc.subjectOutbreaken_US
dc.subjectSchoolen_US
dc.subjectVaccine effectivenessen_US
dc.titleInfluenza vaccine effectiveness estimates against influenza A(H3N2) and A(H1N1) pdm09 among children during school-based outbreaks in the 2016-2017 season in Beijing, China.en_US
dc.typeArticleen_US
dc.identifier.journalHum Vaccin Immunother 2019; advance online publication (ahead of print)en_US
dc.source.journaltitleHuman vaccines & immunotherapeutics


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