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dc.contributor.authorAbete, Itziar
dc.contributor.authorLu, Yunxia
dc.contributor.authorLassale, Camille
dc.contributor.authorVerschuren, Monique
dc.contributor.authorvan der Schouw, Yvonne
dc.contributor.authorBueno-de-Mesquita, Bas
dc.date.accessioned2019-11-08T09:04:22Z
dc.date.available2019-11-08T09:04:22Z
dc.date.issued2019-10-30
dc.identifier.issn2044-6055
dc.identifier.pmid31666267
dc.identifier.doi10.1136/bmjopen-2019-030949
dc.identifier.urihttp://hdl.handle.net/10029/623536
dc.description.abstractAfter an average follow-up of 15.8 years, a total of 936 death cases were identified (466 cancer; 179 CVD; 291 other causes). Statistically significant graded associations between total WCC, and counts of lymphocytes, monocytes, neutrophils and eosinophils and risk of total mortality were observed. These associations were more apparent in current smokers. Strong associations for all-cause mortality or cancer mortality were observed in subjects with BMI ≥25 kg/m2, ever smoking and elevated WCC (HR 3.92, 95% CI 2.76 to 5.57; HR 3.93, 95% CI 2.30 to 6.72). WCC partly mediated the associations between smoking or BMI and all-cause mortality.en_US
dc.language.isoenen_US
dc.subjectmediationen_US
dc.subjectmortalityen_US
dc.subjectobesityen_US
dc.subjectsmokingen_US
dc.subjectwhite cell counten_US
dc.titleWhite cell counts in relation to mortality in a general population of cohort study in the Netherlands: a mediating effect or not?en_US
dc.typeArticleen_US
dc.identifier.journalBMJ Open 2019; 9(10):e030949en_US
dc.source.journaltitleBMJ open


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