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dc.contributor.authorvan den Boogaard, J
dc.contributor.authorRots, NY
dc.contributor.authorvan der Klis, F
dc.contributor.authorde Melker, HE
dc.contributor.authorKnol, MJ
dc.date.accessioned2020-02-14T12:00:48Z
dc.date.available2020-02-14T12:00:48Z
dc.date.issued2020-02-14
dc.identifier.doi10.1016/j.vaccine.2020.01.071
dc.identifier.urihttp://hdl.handle.net/10029/623685
dc.description.abstractIntroduction Socioeconomic status (SES) is a well-known determinant of health, but its relation with vaccine-induced immunity is less documented. We explored the association between SES and immunoglobulin G (IgG) levels against vaccine-preventable diseases in vaccinated children in the Dutch National Immunization Programme. Methods Data from a population-wide cross-sectional serosurvey in the Netherlands (2006–2007) were used. We compared geometric mean IgG concentrations/titers (GMC/T ratios) against measles, mumps, rubella, Haemophilus influenzae type b (Hib), Neisseria meningococcus type C, diphtheria, tetanus, poliovirus types 1,2,3 and pertussis in children of high versus low SES by linear regression analysis. We included 894 children (0–12 years) at one of two timeframes: 1 month to 1 year, or 1–3 years after vaccination. Mother’s educational level and net household income served as binary indicators of SES. Results Of 58 possible associations of vaccine-induced antibody responses with educational level and 58 with income, 10 (9%) were statistically significant: 2 favouring (that is, with higher IgG levels at) high educational level (for Hib 1 m-1y after vaccination (GMC/T ratio: 2.99, 95%CI: 1.42–6.30) and polio 2 1 m-1y after the 9-year booster dose (1.14, 1.01–1.27)) and 8 favouring low income (polio 1, 2 and 3 1 m-1y after the 11-month booster (0.74, 0.58–0.94; 0.79, 0.64–0.97; 0.72, 0.55–0.95), polio 3 and pertussis 1-3y after the 11-month booster (0.70, 0.56–0.88; pertussis-prn: 0.60, 0.37–0.98; pertussis-ptx: 0.66, 0.47–0.95), mumps and rubella 1-3y after first vaccination (0.73, 0.55–0.97; 0.70, 0.55–0.90), and rubella 1 m-1y after second vaccination (0.83, 0.55–0.90)). After adjustment for multiple testing, none of the differences remained significant. There was no association between SES and proportion of children with protective IgG levels.en_US
dc.language.isoenen_US
dc.subjectimmune responseen_US
dc.subjectvaccine preventable diseasesen_US
dc.subjectvaccinationen_US
dc.subjectsocioeconomic statusen_US
dc.subjectnetherlandsen_US
dc.subjectimmunoglobulin Gen_US
dc.titleIs there an association between socioeconomic status and immune response to infant and childhood vaccination in the Netherlands?en_US
dc.typeArticleen_US
dc.identifier.journalVaccine 2020; advance online publication (ahead of print)en_US
refterms.dateFOA2020-02-14T12:00:48Z


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