Show simple item record

dc.contributor.authorKennedy, Marc C
dc.contributor.authorHart, Andy D M
dc.contributor.authorKruisselbrink, Johannes W
dc.contributor.authorvan Lenthe, Marco
dc.contributor.authorde Boer, Waldo J
dc.contributor.authorvan der Voet, Hilko
dc.contributor.authorRorije, Emiel
dc.contributor.authorSprong, Corinne
dc.contributor.authorvan Klaveren, Jacob
dc.date.accessioned2020-07-11T18:52:43Z
dc.date.available2020-07-11T18:52:43Z
dc.date.issued2020-04-01
dc.identifier.issn1873-6351
dc.identifier.pmid32088251
dc.identifier.doi10.1016/j.fct.2020.111223
dc.identifier.urihttp://hdl.handle.net/10029/623926
dc.description.abstractMixtures of substances to which humans are exposed may lead to cumulative exposure and health effects. To study their effects, it is first necessary to identify a cumulative assessment group (CAG) of substances for risk assessment or hazard testing. Excluding substances from consideration before there is sufficient evidence may underestimate the risk. Conversely, including everything and treating the inevitable uncertainties using conservative assumptions is inefficient and may overestimate the risk, with an unknown level of protection. An efficient, transparent strategy is described to retain a large group, quantifying the uncertainty of group membership and other uncertainties. Iterative refinement of the CAG then focuses on adding information for the substances with high probability of contributing significantly to the risk. Probabilities can be estimated using expert opinion or derived from data on substance properties. An example is presented with 100 pesticides, in which the retain step identified a single substance to target refinement. Using an updated hazard characterisation for this substance reduced the mean exposure estimate from 0.43 to 0.28 μg kg-bw-1 day-1 and reduced the 99.99th percentile exposure from 24.9 to 5.1 μg kg-bw-1 day-1. Other retained substances contributed little to the risk estimates, even after accounting for uncertainty.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCumulative assessment groupen_US
dc.subjectMixturesen_US
dc.subjectPesticidesen_US
dc.subjectQSARen_US
dc.subjectRelative potency factoren_US
dc.subjectUncertaintyen_US
dc.titleA retain and refine approach to cumulative risk assessment.en_US
dc.typeArticleen_US
dc.identifier.journalFood Chem Toxicol 2020; 138:111223en_US
dc.source.journaltitleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record