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dc.contributor.authorBrand, Walter
dc.contributor.authorPeters, Ruud J B
dc.contributor.authorBraakhuis, Hedwig M
dc.contributor.authorMaślankiewicz, Lidka
dc.contributor.authorOomen, Agnes G
dc.date.accessioned2020-07-15T19:39:18Z
dc.date.available2020-07-15T19:39:18Z
dc.date.issued2020-07-03
dc.identifier.issn1743-5404
dc.identifier.pmid32619159
dc.identifier.doi10.1080/17435390.2020.1778809
dc.identifier.urihttp://hdl.handle.net/10029/623959
dc.description.abstractRecent studies reported adverse liver effects and intestinal tumor formation after oral exposure to titanium dioxide (TiO2). Other oral toxicological studies, however, observed no effects on liver and intestine, despite prolonged exposure and/or high doses. In the present assessment, we aimed to better understand whether TiO2 can induce such effects at conditions relevant for humans. Therefore, we focused not only on the clinical and histopathological observations, but also used Adverse Outcome Pathways (AOPs) to consider earlier steps (Key Events). In addition, aiming for a more accurate risk assessment, the available information on organ concentrations of Ti (resulting from exposure to TiO2) from oral animal studies was compared to recently reported concentrations found in human postmortem organs. The overview obtained with the AOP approach indicates that TiO2 can trigger a number of key events in liver and intestine: Reactive Oxygen Species (ROS) generation, induction of oxidative stress and inflammation. TiO2 seems to be able to exert these early effects in animal studies at Ti liver concentrations that are only a factor of 30 and 6 times higher than the median and highest liver concentration found in humans, respectively. This confirms earlier conclusions that adverse effects on the liver in humans as a result of (oral) TiO2 exposure cannot be excluded. Data for comparison with Ti levels in human intestinal tissue, spleen and kidney with effect concentrations were too limited to draw firm conclusions. The Ti levels, though, are similar or higher than those found in liver, suggesting these tissues may be relevant too.en_US
dc.language.isoenen_US
dc.subjectAdverse Outcome Pathway (AOP)en_US
dc.subjectTiO2en_US
dc.subjectfood additive E171en_US
dc.subjectinternal organ concentrationen_US
dc.subjectrisk assessmenten_US
dc.titlePossible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure.en_US
dc.typeArticleen_US
dc.identifier.journalNanotoxicology 2020; 14(7):985-1007en_US
dc.source.journaltitleNanotoxicology


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