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dc.contributor.authorHe, Rui-Wen
dc.contributor.authorGerlofs-Nijland, Miriam E
dc.contributor.authorBoere, John
dc.contributor.authorFokkens, Paul
dc.contributor.authorLeseman, Daan
dc.contributor.authorJanssen, Nicole A H
dc.contributor.authorCassee, Flemming R
dc.date.accessioned2020-08-14T09:06:45Z
dc.date.available2020-08-14T09:06:45Z
dc.date.issued2020-07-26
dc.identifier.issn1879-3177
dc.identifier.pmid32726611
dc.identifier.doi10.1016/j.tiv.2020.104950
dc.identifier.urihttp://hdl.handle.net/10029/624019
dc.description.abstractRelatively high concentrations of ultrafine particles (UFPs) have been observed around airports, in which aviation and road traffic emissions are the major sources. This raises concerns about the potential health impacts of airport UFPs, particularly in comparison to those emitted by road traffic. UFPs mainly derived from aviation or road traffic emissions were collected from a location near a major international airport, Amsterdam-Schiphol airport (AMS), depending on the wind direction, along with UFPs from an aircraft turbine engine at low and full thrust. Human bronchial epithelial cells (Calu-3) model in combination with an air-liquid interface (ALI) cloud system was used for the in vitro exposure to UFPs at low doses ranging from 0.09 to 2.07 μg/cm2. Particle size distribution was measured. Cell viability, cytotoxicity and inflammatory potential (interleukin (IL) 6 and 8 secretion) on Calu-3 cells were assessed after exposure for 24 h. The biological measurements on Calu-3 cells confirm that pro-inflammatory responses still can be activated at the high cell viability (> 80%) and low cytotoxicity. By the Benchmark Dose (BMD) analysis, Airport and Non-Airport (road traffic) UFPs as well as UFPs samples from a turbine engine have similar toxic properties. Our results suggest that UFPs from aviation and road traffic in airport surroundings may have similar adverse effects on public health.en_US
dc.language.isoenen_US
dc.subjectAirport emissionen_US
dc.subjectAir–liquid interfaceen_US
dc.subjectBMD analysisen_US
dc.subjectCalu-3 cellen_US
dc.subjectRoad traffic emissionen_US
dc.subjectUFPsen_US
dc.titleComparative toxicity of ultrafine particles around a major airport in human bronchial epithelial (Calu-3) cell model at the air-liquid interface.en_US
dc.typeArticleen_US
dc.identifier.journalToxicol in Vitro 2020; 68:104950en_US
dc.source.journaltitleToxicology in vitro : an international journal published in association with BIBRA


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