Show simple item record

dc.contributor.authorNiehus, Rene
dc.contributor.authorvan Kleef, Esther
dc.contributor.authorMo, Yin
dc.contributor.authorTurlej-Rogacka, Agata
dc.contributor.authorLammens, Christine
dc.contributor.authorCarmeli, Yehuda
dc.contributor.authorGoossens, Herman
dc.contributor.authorTacconelli, Evelina
dc.contributor.authorCarevic, Biljana
dc.contributor.authorPreotescu, Liliana
dc.contributor.authorMalhotra-Kumar, Surbhi
dc.contributor.authorCooper, Ben S
dc.date.accessioned2020-08-14T12:08:57Z
dc.date.available2020-08-14T12:08:57Z
dc.date.issued2020-05-07
dc.identifier.issn2050-084X
dc.identifier.pmid32379042
dc.identifier.doi10.7554/eLife.49206
dc.identifier.urihttp://hdl.handle.net/10029/624061
dc.description.abstractAntibiotic-induced perturbation of the human gut flora is expected to play an important role in mediating the relationship between antibiotic use and the population prevalence of antibiotic resistance in bacteria, but little is known about how antibiotics affect within-host resistance dynamics. Here we develop a data-driven model of the within-host dynamics of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae. We use blaCTX-M (the most widespread ESBL gene family) and 16S rRNA (a proxy for bacterial load) abundance data from 833 rectal swabs from 133 ESBL-positive patients followed up in a prospective cohort study in three European hospitals. We find that cefuroxime and ceftriaxone are associated with increased blaCTX-M abundance during treatment (21% and 10% daily increase, respectively), while treatment with meropenem, piperacillin-tazobactam, and oral ciprofloxacin is associated with decreased blaCTX-M (8% daily decrease for all). The model predicts that typical antibiotic exposures can have substantial long-term effects on blaCTX-M carriage duration.en_US
dc.language.isoenen_US
dc.subjectantibiotic resistanceen_US
dc.subjectepidemiologyen_US
dc.subjectextended-spectrum beta-lactamaseen_US
dc.subjectglobal healthen_US
dc.subjectgut microbiotaen_US
dc.subjecthumanen_US
dc.subjectinfectious diseaseen_US
dc.subjectmicrobiologyen_US
dc.subjectresistance carriageen_US
dc.subjectstate-space modelen_US
dc.subjectwithin-host dynamicsen_US
dc.titleQuantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance.en_US
dc.typeArticleen_US
dc.identifier.journalElife 2020; 9:e49206en_US
dc.source.journaltitleeLife


This item appears in the following Collection(s)

Show simple item record