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dc.contributor.authorFraszczyk, Eliza
dc.contributor.authorLuijten, Mirjam
dc.contributor.authorSpijkerman, Annemieke M W
dc.contributor.authorSnieder, Harold
dc.contributor.authorWackers, Paul F K
dc.contributor.authorBloks, Vincent W
dc.contributor.authorNicoletti, Carolina F
dc.contributor.authorNonino, Carla B
dc.contributor.authorCrujeiras, Ana B
dc.contributor.authorBuurman, Wim A
dc.contributor.authorGreve, Jan Willem
dc.contributor.authorRensen, Sander S
dc.contributor.authorWolffenbuttel, Bruce H R
dc.contributor.authorvan Vliet-Ostaptchouk, Jana V
dc.date.accessioned2020-08-16T15:43:28Z
dc.date.available2020-08-16T15:43:28Z
dc.date.issued2020-01-20
dc.identifier.issn1868-7083
dc.identifier.pmid31959221
dc.identifier.doi10.1186/s13148-019-0790-2
dc.identifier.urihttp://hdl.handle.net/10029/624111
dc.description.abstractTo determine the impact of bariatric surgery and subsequent weight loss on clinical traits, a cohort of 40 severely obese individuals (BMI = 30-73 kg/m2) was examined at the time of surgery and at three follow-up visits, i.e., 3, 6, and 12 months after surgery. The majority of the individuals were women (65%) and the mean age at surgery was 45.1 ± 8.1 years. We observed a significant decrease over time in BMI, fasting glucose, HbA1c, HOMA-IR, insulin, total cholesterol, triglycerides, LDL and free fatty acids levels, and a significant small increase in HDL levels (all p values < 0.05). Epigenome-wide association analysis revealed 4857 differentially methylated CpG sites 12 months after surgery (at Bonferroni-corrected p value < 1.09 × 10-7). Including BMI change in the model decreased the number of significantly differentially methylated CpG sites by 51%. Gene set enrichment analysis identified overrepresentation of multiple processes including regulation of transcription, RNA metabolic, and biosynthetic processes in the cell. Bariatric surgery in severely obese patients resulted in a decrease in both biological age and epigenetic age acceleration (EAA) (mean = - 0.92, p value = 0.039).en_US
dc.language.isoenen_US
dc.subjectBariatric surgeryen_US
dc.subjectBiological ageen_US
dc.subjectDNA methylationen_US
dc.subjectEWASen_US
dc.subjectEpigenetic clocken_US
dc.subjectEpigeneticsen_US
dc.subjectMorbid obesityen_US
dc.subjectObesityen_US
dc.titleThe effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients.en_US
dc.typeArticleen_US
dc.identifier.journalClin Epigenetics 2020; 12(1):14en_US
dc.source.journaltitleClinical epigenetics


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