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dc.contributor.authorvan der Zwaluw, K
dc.contributor.authorWitteveen, S
dc.contributor.authorWielders, L
dc.contributor.authorvan Santen, M
dc.contributor.authorLandman, F
dc.contributor.authorde Haan, A
dc.contributor.authorSchouls, L M
dc.contributor.authorBosch, T
dc.date.accessioned2020-08-16T19:36:32Z
dc.date.available2020-08-16T19:36:32Z
dc.date.issued2020-02-05
dc.identifier.issn1469-0691
dc.identifier.pmid32006688
dc.identifier.doi10.1016/j.cmi.2020.01.027
dc.identifier.urihttp://hdl.handle.net/10029/624129
dc.description.abstractIn total, 1838 unique isolates were received between 2014 and 2018, of which 892 were unique CPE isolates with NGS data available. The predominant CPE species were Klebsiella pneumoniae (n = 388, 43%), Escherichia coli (n = 264, 30%) and Enterobacter cloacae complex (n = 116, 13%). Various carbapenemase alleles of the same carbapenemase gene resulted in different susceptibilities to meropenem and this effect varied between species. Analyses of NGS data showed variation of prevalence of carbapenemase alleles over time with blaOXA-48 being predominant (38%, 336/892), followed by blaNDM-1 (16%, 145/892). For the first time in the Netherlands, blaOXA-181, blaOXA-232 and blaVIM-4 were detected. The genetic background of K. pneumoniae and E. coli isolates was highly diverse.en_US
dc.language.isoenen_US
dc.subjectCPEen_US
dc.subjectCarbapenemase activityen_US
dc.subjectCarbapenemase genesen_US
dc.subjectNGSen_US
dc.subjectSurveillanceen_US
dc.titleMolecular characteristics of carbapenemase-producing Enterobacterales in the Netherlands; results of the 2014-2018 national laboratory surveillance.en_US
dc.typeArticleen_US
dc.identifier.journalClin Microb Infect 2020; 26(10):1412.e7-1412.e12en_US
dc.source.journaltitleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases


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