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dc.contributor.authorSeyed Khoei, Nazlisadat
dc.contributor.authorJenab, Mazda
dc.contributor.authorMurphy, Neil
dc.contributor.authorBanbury, Barbara L
dc.contributor.authorCarreras-Torres, Robert
dc.contributor.authorViallon, Vivian
dc.contributor.authorKühn, Tilman
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorCross, Amanda J
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorStepien, Magdalena
dc.contributor.authorBulmer, Andrew
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorCarbonnel, Franck
dc.contributor.authorKatzke, Verena
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBergmann, Manuela M
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorMartimianaki, Georgia
dc.contributor.authorPalli, Domenico
dc.contributor.authorTagliabue, Giovanna
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorSkeie, Guri
dc.contributor.authorMerino, Susana
dc.contributor.authorBonet, Catalina
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorGil, Leire
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorMyte, Robin
dc.contributor.authorHultdin, Johan
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorAune, Dagfinn
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorBaron, John A
dc.contributor.authorBerndt, Sonja I
dc.contributor.authorBézieau, Stéphane
dc.contributor.authorBrenner, Hermann
dc.contributor.authorCampbell, Peter T
dc.contributor.authorCasey, Graham
dc.contributor.authorChan, Andrew T
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorChanock, Stephen J
dc.contributor.authorCotterchio, Michelle
dc.contributor.authorGallinger, Steven
dc.contributor.authorGruber, Stephen B
dc.contributor.authorHaile, Robert W
dc.contributor.authorHampe, Jochen
dc.contributor.authorHoffmeister, Michael
dc.contributor.authorHopper, John L
dc.contributor.authorHsu, Li
dc.contributor.authorHuyghe, Jeroen R
dc.contributor.authorJenkins, Mark A
dc.contributor.authorJoshi, Amit D
dc.contributor.authorKampman, Ellen
dc.contributor.authorLarsson, Susanna C
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorLi, Christopher I
dc.contributor.authorLi, Li
dc.contributor.authorLindblom, Annika
dc.contributor.authorLindor, Noralane M
dc.contributor.authorMartín, Vicente
dc.contributor.authorMoreno, Victor
dc.contributor.authorNewcomb, Polly A
dc.contributor.authorOffit, Kenneth
dc.contributor.authorOgino, Shuji
dc.contributor.authorParfrey, Patrick S
dc.contributor.authorPharoah, Paul D P
dc.contributor.authorRennert, Gad
dc.contributor.authorSakoda, Lori C
dc.contributor.authorSchafmayer, Clemens
dc.contributor.authorSchmit, Stephanie L
dc.contributor.authorSchoen, Robert E
dc.contributor.authorSlattery, Martha L
dc.contributor.authorThibodeau, Stephen N
dc.contributor.authorUlrich, Cornelia M
dc.contributor.authorvan Duijnhoven, Franzel J B
dc.contributor.authorWeigl, Korbinian
dc.contributor.authorWeinstein, Stephanie J
dc.contributor.authorWhite, Emily
dc.contributor.authorWolk, Alicja
dc.contributor.authorWoods, Michael O
dc.contributor.authorWu, Anna H
dc.contributor.authorZhang, Xuehong
dc.contributor.authorFerrari, Pietro
dc.contributor.authorAnton, Gabriele
dc.contributor.authorPeters, Annette
dc.contributor.authorPeters, Ulrike
dc.contributor.authorGunter, Marc J
dc.contributor.authorWagner, Karl-Heinz
dc.contributor.authorFreisling, Heinz
dc.date.accessioned2020-09-27T09:30:35Z
dc.date.available2020-09-27T09:30:35Z
dc.date.issued2020-09-03
dc.identifier.issn1741-7015
dc.identifier.pmid32878631
dc.identifier.doi10.1186/s12916-020-01703-w
dc.identifier.urihttp://hdl.handle.net/10029/624378
dc.description.abstractIn a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10-8) with circulating total bilirubin were instrumented in a 2-sample MR to test for a potential causal effect of bilirubin on CRC risk in 52,775 CRC cases and 45,940 matched controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colon Cancer Family Registry (CCFR), and the Colorectal Transdisciplinary (CORECT) study.en_US
dc.language.isoenen_US
dc.subjectAnti-oxidantsen_US
dc.subjectBilirubinen_US
dc.subjectCanceren_US
dc.subjectColorectal canceren_US
dc.subjectMendelian randomization analysisen_US
dc.titleCirculating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.en_US
dc.typeArticleen_US
dc.identifier.journalBMC Medicine 2020; 18(1):229en_US
dc.source.journaltitleBMC medicine


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