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dc.contributor.authorLanfermeijer, Josien
dc.contributor.authorBorghans, José A M
dc.contributor.authorvan Baarle, Debbie
dc.date.accessioned2020-11-12T11:42:32Z
dc.date.available2020-11-12T11:42:32Z
dc.date.issued2020-10-20
dc.identifier.issn1474-9726
dc.identifier.pmid33078890
dc.identifier.doi10.1111/acel.13262
dc.identifier.urihttp://hdl.handle.net/10029/624488
dc.description.abstractOlder adults often show signs of impaired CD8+ T-cell immunity, reflected by weaker responses against new infections and vaccinations, and decreased protection against reinfection. This immune impairment is in part thought to be the consequence of a decrease in both T-cell numbers and repertoire diversity. If this is indeed the case, a strategy to prevent infectious diseases in older adults could be the induction of protective memory responses through vaccination at a younger age. However, this requires that the induced immune responses are maintained until old age. It is therefore important to obtain insights into the long-term maintenance of the antigen-specific T-cell repertoire. Here, we review the literature on the maintenance of antigen-experienced CD8+ T-cell repertoires against acute and chronic infections. We describe the complex interactions that play a role in shaping the memory T-cell repertoire, and the effects of age, infection history, and T-cell avidity. We discuss the implications of these findings for the development of new vaccination strategies to protect older adults.en_US
dc.language.isoenen_US
dc.subjectCD8+ T-cellen_US
dc.subjectT-cell receptoren_US
dc.subjectagingen_US
dc.subjectinfection historyen_US
dc.subjectrepertoireen_US
dc.subjectvaccinationen_US
dc.titleHow age and infection history shape the antigen-specific CD8 T-cell repertoire: Implications for vaccination strategies in older adults.en_US
dc.typeArticleen_US
dc.identifier.journalAging Cell 2020; e13262 advance online publication (ahead of print)en_US
dc.source.journaltitleAging cell


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