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dc.contributor.authorLe, T T Yen
dc.contributor.authorGrabner, Daniel
dc.contributor.authorNachev, Milen
dc.contributor.authorPeijnenburg, Willi J G M
dc.contributor.authorHendriks, A Jan
dc.contributor.authorSures, Bernd
dc.date.accessioned2021-01-25T10:36:01Z
dc.date.available2021-01-25T10:36:01Z
dc.date.issued2020-12-11
dc.identifier.pmid33341731
dc.identifier.doi10.1016/j.chemosphere.2020.129278
dc.identifier.urihttp://hdl.handle.net/10029/624656
dc.description.abstractThe stenohaline zebra mussel, Dreissena polymorpha, is uniquely sensitive to the ionic composition of its aquatic environment. Waterborne copper (Cu) uptake and accumulation in zebra mussels were examined at various conditions in an environmentally relevant range in freshwater, i.e. Cu exposure levels (nominal concentrations of 25 and 50 μg/L), pH (5.8-8.3), and sodium (Na+) concentrations (up to 4.0 mM). Copper accumulation was simulated by a kinetic model covering two compartments, the gills and the remaining tissues. The Cu uptake rate constant decreased with decreasing pH from 8.3 down to 6.5, indicating interactions between H+ and Cu at uptake sites. The kinetic simulation showed dose-dependent effects of Na+ on Cu uptake. At 25 μg/L Cu, addition of Na+ at 0.5 mM significantly inhibited the Cu uptake rate, while no significant differences were found in the uptake rate upon further addition of Na+ up to a concentration of 4.0 mM. At 50 μg/L Cu, the Cu uptake rate was not influenced by Na+ addition. Calibration results exhibited dose-dependent elimination rates with more profound elimination with increasing exposure levels. With kinetic parameters calibrated at environmentally relevant conditions, in terms of pH and Na+ concentrations, the model performed well in predicting Cu accumulation based on independent data sets. Estimates of the Cu concentration in mussels were within a factor of 2 of the measurements. This demonstrates potential application of kinetic models that are calibrated in environmentally relevant freshwater conditions.en_US
dc.language.isoenen_US
dc.rightsCopyright © 2020 Elsevier Ltd. All rights reserved.
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBioaccumulationen_US
dc.subjectBivalveen_US
dc.subjectEliminationen_US
dc.subjectKinetic modelen_US
dc.subjectMetalen_US
dc.subjectUptakeen_US
dc.titleModelling copper toxicokinetics in the zebra mussel, Dreissena polymorpha, under chronic exposures at various pH and sodium concentrations.en_US
dc.typeArticleen_US
dc.identifier.eissn1879-1298
dc.identifier.journalChemosphere 2021; 267:129278en_US
dc.source.journaltitleChemosphere
dc.source.volume267
dc.source.beginpage129278
dc.source.endpage
dc.source.countryEngland


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