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dc.contributor.authorFrost, Joe N
dc.contributor.authorTan, Tiong Kit
dc.contributor.authorAbbas, Munawar
dc.contributor.authorWideman, Sarah K
dc.contributor.authorBonadonna, Michael
dc.contributor.authorStoffel, Nicole U
dc.contributor.authorWray, Katherine
dc.contributor.authorKronsteiner, Barbara
dc.contributor.authorSmits, Gaby
dc.contributor.authorCampagna, Dean R
dc.contributor.authorDuarte, Tiago L
dc.contributor.authorLopes, José M
dc.contributor.authorShah, Akshay
dc.contributor.authorArmitage, Andrew E
dc.contributor.authorArezes, João
dc.contributor.authorLim, Pei Jin
dc.contributor.authorPreston, Alexandra E
dc.contributor.authorAhern, David
dc.contributor.authorTeh, Megan
dc.contributor.authorNaylor, Caitlin
dc.contributor.authorSalio, Mariolina
dc.contributor.authorGileadi, Uzi
dc.contributor.authorAndrews, Simon C
dc.contributor.authorDunachie, Susanna J
dc.contributor.authorZimmermann, Michael B
dc.contributor.authorvan der Klis, Fiona R M
dc.contributor.authorCerundolo, Vincenzo
dc.contributor.authorBannard, Oliver
dc.contributor.authorDraper, Simon J
dc.contributor.authorTownsend, Alain R M
dc.contributor.authorGaly, Bruno
dc.contributor.authorFleming, Mark D
dc.contributor.authorLewis, Marie C
dc.contributor.authorDrakesmith, Hal
dc.date.accessioned2021-03-16T14:45:15Z
dc.date.available2021-03-16T14:45:15Z
dc.identifier.pmid33665641
dc.identifier.doi10.1016/j.medj.2020.10.004
dc.identifier.urihttp://hdl.handle.net/10029/624777
dc.description.abstractWe used a hepcidin mimetic and several genetic models to examine the effect of low iron availability on T cells in vitro and on immune responses to vaccines and viral infection in mice. We examined humoral immunity in human patients with raised hepcidin and low serum iron caused by mutant TMPRSS6. We tested the effect of iron supplementation on vaccination-induced humoral immunity in piglets, a natural model of iron deficiency.en_US
dc.language.isoenen_US
dc.rights© 2020 The Authors.
dc.subjectT-cellsen_US
dc.subjectadaptive immunityen_US
dc.subjectglobal healthen_US
dc.subjecthepcidinen_US
dc.subjecthypoferremiaen_US
dc.subjectimmunometabolismen_US
dc.subjectinfectionen_US
dc.subjectinfluenza virusen_US
dc.subjectironen_US
dc.subjectvaccinationen_US
dc.titleHepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.en_US
dc.typeArticleen_US
dc.identifier.eissn2666-6340
dc.identifier.journalMed (New York, N.Y.)en_US
dc.source.journaltitleMed (New York, N.Y.)
dc.source.volume2
dc.source.issue2
dc.source.beginpage164
dc.source.endpage179.e12
dc.source.countryUnited Kingdom
dc.source.countryUnited States


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