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dc.contributor.authorGigliucci, Federica
dc.contributor.authorvan Hoek, Angela H A M
dc.contributor.authorChiani, Paola
dc.contributor.authorKnijn, Arnold
dc.contributor.authorMinelli, Fabio
dc.contributor.authorScavia, Gaia
dc.contributor.authorFranz, Eelco
dc.contributor.authorMorabito, Stefano
dc.contributor.authorMichelacci, Valeria
dc.date.accessioned2021-04-18T19:07:47Z
dc.date.available2021-04-18T19:07:47Z
dc.identifier.pmid33622476
dc.identifier.doi10.3201/eid2703.203110
dc.identifier.urihttp://hdl.handle.net/10029/624821
dc.description.abstractShiga toxin-producing Escherichia coli (STEC) O80:H2 has emerged in Europe as a cause of hemolytic uremic syndrome associated with bacteremia. STEC O80:H2 harbors the mosaic plasmid pR444_A, which combines several virulence genes, including hlyF and antimicrobial resistance genes. pR444_A is found in some extraintestinal pathogenic E. coli (ExPEC) strains. We identified and characterized 53 STEC strains with ExPEC-associated virulence genes isolated in Italy and the Netherlands during 2000-2019. The isolates belong to 2 major populations: 1 belongs to sequence type 301 and harbors diverse stx2 subtypes, the intimin variant eae-ξ, and pO157-like and pR444_A plasmids; 1 consists of strains belonging to various sequence types, some of which lack the pO157 plasmid, the locus of enterocyte effacement, and the antimicrobial resistance-encoding region. Our results showed that STEC strains harboring ExPEC-associated virulence genes can include multiple serotypes and that the pR444_A plasmid can be acquired and mobilized by STEC strains.en_US
dc.language.isoenen_US
dc.subjectEscherichia colien_US
dc.subjectExPECen_US
dc.subjectItalyen_US
dc.subjectSTECen_US
dc.subjectShiga toxin–producing Escherichia colien_US
dc.subjectantimicrobial resistanceen_US
dc.subjectbacteriaen_US
dc.subjectbacterial zoonosesen_US
dc.subjectenteric infectionsen_US
dc.subjectextraintestinal pathogenic E. colien_US
dc.subjectfood safetyen_US
dc.subjectfoodborne diseaseen_US
dc.subjecthemolytic uremic syndromeen_US
dc.subjecthlyFen_US
dc.subjectphylogenesisen_US
dc.subjectthe Netherlandsen_US
dc.subjectwhole-genome sequencingen_US
dc.subjectzoonosesen_US
dc.titleGenomic Characterization of hlyF-positive Shiga Toxin-Producing Escherichia coli, Italy and the Netherlands, 2000-2019.en_US
dc.typeArticleen_US
dc.identifier.eissn1080-6059
dc.identifier.journalEmerg Infect Dis 2021; 27(3):853-61en_US
dc.source.journaltitleEmerging infectious diseases
dc.source.volume27
dc.source.issue3
dc.source.beginpage853
dc.source.endpage861
dc.source.countryUnited States


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