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dc.contributor.authorCzepiel, Jacek
dc.contributor.authorKrutova, Marcela
dc.contributor.authorMizrahi, Assaf
dc.contributor.authorKhanafer, Nagham
dc.contributor.authorEnoch, David A
dc.contributor.authorPatyi, Márta
dc.contributor.authorDeptuła, Aleksander
dc.contributor.authorAgodi, Antonella
dc.contributor.authorNuvials, Xavier
dc.contributor.authorPituch, Hanna
dc.contributor.authorWójcik-Bugajska, Małgorzata
dc.contributor.authorFilipczak-Bryniarska, Iwona
dc.contributor.authorBrzozowski, Bartosz
dc.contributor.authorKrzanowski, Marcin
dc.contributor.authorKonturek, Katarzyna
dc.contributor.authorFedewicz, Marcin
dc.contributor.authorMichalak, Mateusz
dc.contributor.authorMonpierre, Lorra
dc.contributor.authorVanhems, Philippe
dc.contributor.authorGouliouris, Theodore
dc.contributor.authorJurczyszyn, Artur
dc.contributor.authorGoldman-Mazur, Sarah
dc.contributor.authorWultańska, Dorota
dc.contributor.authorKuijper, Ed J
dc.contributor.authorSkupień, Jan
dc.contributor.authorBiesiada, Grażyna
dc.contributor.authorGarlicki, Aleksander
dc.date.accessioned2021-04-19T08:27:39Z
dc.date.available2021-04-19T08:27:39Z
dc.date.issued2021-03-13
dc.identifier.issn2079-6382
dc.identifier.pmid33805755
dc.identifier.doi10.3390/antibiotics10030299
dc.identifier.urihttp://hdl.handle.net/10029/624831
dc.description.abstractWe aimed to describe the clinical presentation, treatment, outcome and report on factors associated with mortality over a 90-day period in Clostridioides difficile infection (CDI). Descriptive, univariate, and multivariate regression analyses were performed on data collected in a retrospective case-control study conducted in nine hospitals from seven European countries. A total of 624 patients were included, of which 415 were deceased (cases) and 209 were still alive 90 days after a CDI diagnosis (controls). The most common antibiotics used previously in both groups were β-lactams; previous exposure to fluoroquinolones was significantly (p = 0.0004) greater in deceased patients. Multivariate logistic regression showed that the factors independently related with death during CDI were older age, inadequate CDI therapy, cachexia, malignancy, Charlson Index, long-term care, elevated white blood cell count (WBC), C-reactive protein (CRP), bacteraemia, complications, and cognitive impairment. In addition, older age, higher levels of WBC, neutrophil, CRP or creatinine, the presence of malignancy, cognitive impairment, and complications were strongly correlated with shortening the time from CDI diagnosis to death. CDI prevention should be primarily focused on hospitalised elderly people receiving antibiotics. WBC, neutrophil count, CRP, creatinine, albumin and lactate levels should be tested in every hospitalised patient treated for CDI to assess the risk of a fatal outcome.en_US
dc.language.isoenen_US
dc.subjectClostridioides difficile infectionen_US
dc.subjectco–morbiditiesen_US
dc.subjectmalignancyen_US
dc.subjectmortalityen_US
dc.subjectoutcomeen_US
dc.subjectrisk factorsen_US
dc.titleMortality Following Infection in Europe: A Retrospective Multicenter Case-Control Study.en_US
dc.typeArticleen_US
dc.identifier.journalAntibiotics 2021; 10(3):299en_US
dc.source.journaltitleAntibiotics (Basel, Switzerland)
dc.source.volume10
dc.source.issue3
dc.source.countrySwitzerland


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