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dc.contributor.authorBennett, Julia C
dc.contributor.authorHetrich, Marissa K
dc.contributor.authorQuesada, Maria Garcia
dc.contributor.authorSinkevitch, Jenna N
dc.contributor.authorKnoll, Maria Deloria
dc.contributor.authorFeikin, Daniel R
dc.contributor.authorZeger, Scott L
dc.contributor.authorKagucia, Eunice W
dc.contributor.authorCohen, Adam L
dc.contributor.authorAmpofo, Krow
dc.contributor.authorBrandileone, Maria-Cristina C
dc.contributor.authorBruden, Dana
dc.contributor.authorCamilli, Romina
dc.contributor.authorCastilla, Jesús
dc.contributor.authorChan, Guanhao
dc.contributor.authorCook, Heather
dc.contributor.authorCornick, Jennifer E
dc.contributor.authorDagan, Ron
dc.contributor.authorDalby, Tine
dc.contributor.authorDanis, Kostas
dc.contributor.authorMiguel, Sara de
dc.contributor.authorWals, Philippe De
dc.contributor.authorDesmet, Stefanie
dc.contributor.authorGeorgakopoulou, Theano
dc.contributor.authorGilkison, Charlotte
dc.contributor.authorGrgic-Vitek, Marta
dc.contributor.authorHammitt, Laura L
dc.contributor.authorHilty, Markus
dc.contributor.authorHo, Pak-Leung
dc.contributor.authorJayasinghe, Sanjay
dc.contributor.authorKellner, James D
dc.contributor.authorKleynhans, Jackie
dc.contributor.authorKnol, Mirjam J
dc.contributor.authorKozakova, Jana
dc.contributor.authorKristinsson, Karl G
dc.contributor.authorLadhani, Shamez N
dc.contributor.authorMacDonald, Laura
dc.contributor.authorMackenzie, Grant A
dc.contributor.authorMad'arová, Lucia
dc.contributor.authorMcGeer, Allison
dc.contributor.authorMereckiene, Jolita
dc.contributor.authorMorfeldt, Eva
dc.contributor.authorMungun, Tuya
dc.contributor.authorMuñoz-Almagro, Carmen
dc.contributor.authorNuorti, J Pekka
dc.contributor.authorParagi, Metka
dc.contributor.authorPilishvili, Tamara
dc.contributor.authorPuentes, Rodrigo
dc.contributor.authorSaha, Samir K
dc.contributor.authorKhan, Aalisha Sahu
dc.contributor.authorSavrasova, Larisa
dc.contributor.authorScott, J Anthony
dc.contributor.authorSkoczyńska, Anna
dc.contributor.authorSuga, Shigeru
dc.contributor.authorLinden, Mark van der
dc.contributor.authorVerani, Jennifer R
dc.contributor.authorGottberg, Anne von
dc.contributor.authorWinje, Brita A
dc.contributor.authorYildirim, Inci
dc.contributor.authorZerouali, Khalid
dc.contributor.authorHayford, Kyla
dc.contributor.authorThe Pserenade Team
dc.date.accessioned2021-04-19T08:47:27Z
dc.date.available2021-04-19T08:47:27Z
dc.date.issued2021-03-27
dc.identifier.issn2076-2607
dc.identifier.pmid33801760
dc.identifier.doi10.3390/microorganisms9040696
dc.identifier.urihttp://hdl.handle.net/10029/624842
dc.description.abstractStreptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST1 IPD surveillance data from sites globally and aimed to estimate PCV10/13 impact on ST1 IPD incidence. We estimated ST1 IPD incidence rate ratios (IRRs) comparing the pre-PCV10/13 period to each post-PCV10/13 year by site using a Bayesian multi-level, mixed-effects Poisson regression and all-site IRRs using a linear mixed-effects regression (N = 45 sites). Following PCV10/13 introduction, the incidence rate (IR) of ST1 IPD declined among all ages. After six years of PCV10/13 use, the all-site IRR was 0.05 (95% credibility interval 0.04-0.06) for all ages, 0.05 (0.04-0.05) for <5 years of age, 0.08 (0.06-0.09) for 5-17 years, 0.06 (0.05-0.08) for 18-49 years, 0.06 (0.05-0.07) for 50-64 years, and 0.05 (0.04-0.06) for ≥65 years. PCV10/13 use in infant immunization programs was followed by a 95% reduction in ST1 IPD in all ages after approximately 6 years. Limited data availability from the highest ST1 disease burden countries using a 3+0 schedule constrains generalizability and data from these settings are needed.en_US
dc.language.isoenen_US
dc.subjectinvasive pneumococcal diseaseen_US
dc.subjectpneumococcal conjugate vaccinesen_US
dc.subjectserotypesen_US
dc.subjectvaccine impacten_US
dc.titleChanges in Invasive Pneumococcal Disease Caused by Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.en_US
dc.typeArticleen_US
dc.identifier.journalMicroorganism 2021; 9(4):696en_US
dc.source.journaltitleMicroorganisms
dc.source.volume9
dc.source.issue4
dc.source.countrySwitzerland


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