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dc.contributor.authorPieren, Daan K J
dc.contributor.authorSmits, Noortje A M
dc.contributor.authorHoeboer, Jeroen
dc.contributor.authorKandiah, Vinitha
dc.contributor.authorPostel, Rimke J
dc.contributor.authorMariman, Rob
dc.contributor.authorvan Beek, Josine
dc.contributor.authorvan Baarle, Debbie
dc.contributor.authorde Wit, Jelle
dc.contributor.authorGuichelaar, Teun
dc.date.accessioned2021-07-12T08:42:35Z
dc.date.available2021-07-12T08:42:35Z
dc.date.issued2021-05-27
dc.identifier.pmid34043881
dc.identifier.doi10.1111/acel.13372
dc.identifier.urihttp://hdl.handle.net/10029/625033
dc.description.abstractSevere respiratory viral infectious diseases such as influenza and COVID-19 especially affect the older population. This is partly ascribed to diminished CD8+ T-cell responses a result of aging. The phenotypical diversity of the CD8+ T-cell population has made it difficult to identify the impact of aging on CD8+ T-cell subsets associated with diminished CD8+ T-cell responses. Here we identify a novel human CD8+ T-cell subset characterized by expression of Killer-cell Immunoglobulin-like Receptors (KIR+ ) and CD45RA (RA+ ). These KIR+ RA+ T cells accumulated with age in the blood of healthy individuals (20-82 years of age, n = 50), expressed high levels of aging-related markers of T-cell regulation, and were functionally capable of suppressing proliferation of other CD8+ T cells. Moreover, KIR+ RA+ T cells were a major T-cell subset becoming activated in older adults suffering from an acute respiratory viral infection (n = 36), including coronavirus and influenza virus infection. In addition, older adults with influenza A infection showed that higher activation status of their KIR+ RA+ T cells associated with longer duration of respiratory symptoms. Together, our data indicate that KIR+ RA+ T cells are a unique human T-cell subset with regulatory properties that may explain susceptibility to viral respiratory disease at old age.en_US
dc.language.isoenen_US
dc.rights© 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
dc.subjectCD8+ T cellsen_US
dc.subjectT-cell activationen_US
dc.subjectagingen_US
dc.subjectkiller-cell immunoglobulin-like receptorsen_US
dc.subjectregulatory T cellsen_US
dc.subjectrespiratory viral infectionen_US
dc.subjectviral respiratory diseaseen_US
dc.titleRegulatory KIR RA T cells accumulate with age and are highly activated during viral respiratory disease.en_US
dc.typeArticleen_US
dc.identifier.eissn1474-9726
dc.identifier.journalAging Cell 2021; e13372en_US
dc.source.journaltitleAging cell
dc.source.volume20
dc.source.issue6
dc.source.beginpagee13372
dc.source.endpage
dc.source.countryEngland


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