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dc.contributor.authorIbi, Dorina
dc.contributor.authorBlauw, Lisanne L
dc.contributor.authorNoordam, Raymond
dc.contributor.authorDollé, Martijn E T
dc.contributor.authorJukema, J Wouter
dc.contributor.authorRosendaal, Frits R
dc.contributor.authorChristodoulides, Constantinos
dc.contributor.authorNeville, Matt J
dc.contributor.authorKoivula, Robert
dc.contributor.authorRensen, Patrick C N
dc.contributor.authorKarpe, Fredrik
dc.contributor.authorvan Dijk, Ko Willems
dc.date.accessioned2021-07-12T09:11:59Z
dc.date.available2021-07-12T09:11:59Z
dc.date.issued2021-05-09
dc.identifier.pmid34053745
dc.identifier.doi10.1016/j.atherosclerosis.2021.04.015
dc.identifier.urihttp://hdl.handle.net/10029/625050
dc.description.abstractCompared to the individual groups with genetically-influenced lower TG or lower LDL-C only, the group with combined genetically-influenced lower TG and LDL-C showed an overall independent and additive pattern of changes in metabolomic measures. Over 100 measures were different (p < 1.35 × 10-3) compared to the reference, with effect sizes and directionality being similar in NEO and OBB. Most notably, levels of all very-low density lipoprotein (VLDL) and LDL sub-particles were lower.en_US
dc.language.isoenen_US
dc.rightsCopyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
dc.subjectCardiovascular diseaseen_US
dc.subjectLDL-Cholesterol-loweringen_US
dc.subjectLipoprotein lipaseen_US
dc.subjectMendelian randomizationen_US
dc.subjectMetabolomicsen_US
dc.subjectTriglyceride-loweringen_US
dc.titleTriglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile.en_US
dc.typeArticleen_US
dc.identifier.eissn1879-1484
dc.identifier.journalAtherosclerosis 2021; 328:144-52en_US
dc.source.journaltitleAtherosclerosis
dc.source.volume328
dc.source.beginpage144
dc.source.endpage152
dc.source.countryIreland


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