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dc.contributor.authorSieswerda, Elske
dc.contributor.authorBosch, Thijs
dc.contributor.authorLankelma, Jacqueline M
dc.contributor.authorSchouls, Leo M
dc.contributor.authorDijk, Karin van
dc.date.accessioned2021-07-15T19:24:22Z
dc.date.available2021-07-15T19:24:22Z
dc.date.issued2021-07-07
dc.identifier.pmid34229445
dc.identifier.doi10.2217/fmb-2020-0024
dc.identifier.urihttp://hdl.handle.net/10029/625079
dc.description.abstractAim: To define sensitivity and specificity of Vitek® 2 MICs as phenotypic screening method for carbapenemase-producing Pseudomonas aeruginosa. Materials & methods: We determined Vitek® 2 MICs of antipseudomonal antimicrobials in 130 unrelated carbapenemase-producing P. aeruginosa and 129 carbapenemase-negative P. aeruginosa isolates within a Dutch carbapenemase-surveillance database. We calculated test characteristics of single and combined antimicrobial MICs for carbapenemase production. Results: Vitek® 2 MIC above epidemiological cutoff of both imipenem and tobramycin or ciprofloxacin and tobramycin displayed a sensitivity of 96.2% and specificity of 89.6% for carbapenemase production in P. aeruginosa. Conclusion: Vitek® 2 MIC> epidemiological cut-off values seem sensitive and specific as a phenotypic screening strategy for carbapenemase-producing P. aeruginosa. Combining imipenem and tobramycin or ciprofloxacin and tobramycin performed best as a screening strategy for defining which P. aeruginosa isolates should undergo confirmatory tests for carbapenemase production.en_US
dc.language.isoenen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectantimicrobial susceptibility testingen_US
dc.subjectbacterial drug resistanceen_US
dc.subjectcarbapenemaseen_US
dc.titleVitek 2 MICs as first-line phenotypic screening method for carbapenemase-producing .en_US
dc.typeArticleen_US
dc.identifier.eissn1746-0921
dc.identifier.journalFuture Microbiol 2021; 16(11):777-81en_US
dc.source.journaltitleFuture microbiology
dc.source.countryEngland


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