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dc.contributor.authorBanu, Regina Ama
dc.contributor.authorAlvarez, Jorge Matheu
dc.contributor.authorReid, Anthony J
dc.contributor.authorEnbiale, Wendemagegn
dc.contributor.authorLabi, Appiah-Korang
dc.contributor.authorAnsa, Ebenezer D O
dc.contributor.authorAnnan, Edith Andrews
dc.contributor.authorAkrong, Mark Osa
dc.contributor.authorBorbor, Selorm
dc.contributor.authorAdomako, Lady A B
dc.contributor.authorAhmed, Hawa
dc.contributor.authorMustapha, Mohammed Bello
dc.contributor.authorDavtyan, Hayk
dc.contributor.authorOwiti, Phillip
dc.contributor.authorHedidor, George Kwesi
dc.contributor.authorQuarcoo, Gerard
dc.contributor.authorOpare, David
dc.contributor.authorKikimoto, Boi
dc.contributor.authorOsei-Atwenebanoa, Mike Y
dc.contributor.authorSchmitt, Heike
dc.date.accessioned2021-07-15T19:45:30Z
dc.date.available2021-07-15T19:45:30Z
dc.date.issued2021-06-20
dc.identifier.pmid34203078
dc.identifier.doi10.3390/tropicalmed6020105
dc.identifier.urihttp://hdl.handle.net/10029/625094
dc.description.abstractInfections by Extended-Spectrum Beta-Lactamase producing Escherichia coli (ESBL-Ec) are on the increase in Ghana, but the level of environmental contamination with this organism, which may contribute to growing Antimicrobial Resistance (AMR), is unknown. Using the WHO OneHealth Tricycle Protocol, we investigated the contamination of E. coli (Ec) and ESBL-Ec in two rivers in Ghana (Odaw in Accra and Okurudu in Kasoa) that receive effluents from human and animal wastewater hotspots over a 12-month period. Concentrations of Ec, ESBL-Ec and percent ESBL-Ec/Ec were determined per 100 mL sample. Of 96 samples, 94 (98%) were positive for ESBL-Ec. concentrations per 100 mL (MCs100) of ESBL-Ec and %ESBL-Ec from both rivers were 4.2 × 104 (IQR, 3.1 × 103-2.3 × 105) and 2.79 (IQR, 0.96-6.03), respectively. MCs100 were significantly lower in upstream waters: 1.8 × 104 (IQR, 9.0 × 103-3.9 × 104) as compared to downstream waters: 1.9 × 106 (IQR, 3.7 × 105-5.4 × 106). Both human and animal wastewater effluents contributed to the increased contamination downstream. This study revealed high levels of ESBL-Ec in rivers flowing through two cities in Ghana. There is a need to manage the sources of contamination as they may contribute to the acquisition and spread of ESBL-Ec in humans and animals, thereby contributing to AMR.en_US
dc.language.isoenen_US
dc.subjectESBL-E. colien_US
dc.subjectGhanaen_US
dc.subjectantimicrobial resistanceen_US
dc.subjectenvironmenten_US
dc.subjectoperational researchen_US
dc.subjectriversen_US
dc.subjectsort iten_US
dc.subjecttricycle protocolen_US
dc.titleExtended Spectrum Beta-Lactamase in River Waters Collected from Two Cities in Ghana, 2018-2020.en_US
dc.typeArticleen_US
dc.identifier.eissn2414-6366
dc.identifier.journalTrop Med Infect Dis 2021; 6(2):105en_US
dc.source.journaltitleTropical medicine and infectious disease
dc.source.volume6
dc.source.issue2
dc.source.countrySwitzerland


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