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dc.contributor.authorSchneider, Julia
dc.contributor.authorHoffmann, Bernd
dc.contributor.authorFevola, Cristina
dc.contributor.authorSchmidt, Marie Luisa
dc.contributor.authorImholt, Christian
dc.contributor.authorFischer, Stefan
dc.contributor.authorEcke, Frauke
dc.contributor.authorHörnfeldt, Birger
dc.contributor.authorMagnusson, Magnus
dc.contributor.authorOlsson, Gert E
dc.contributor.authorRizzoli, Annapaola
dc.contributor.authorTagliapietra, Valentina
dc.contributor.authorChiari, Mario
dc.contributor.authorReusken, Chantal
dc.contributor.authorBužan, Elena
dc.contributor.authorKazimirova, Maria
dc.contributor.authorStanko, Michal
dc.contributor.authorWhite, Thomas A
dc.contributor.authorReil, Daniela
dc.contributor.authorObiegala, Anna
dc.contributor.authorMeredith, Anna
dc.contributor.authorDrexler, Jan Felix
dc.contributor.authorEssbauer, Sandra
dc.contributor.authorHenttonen, Heikki
dc.contributor.authorJacob, Jens
dc.contributor.authorHauffe, Heidi C
dc.contributor.authorBeer, Martin
dc.contributor.authorHeckel, Gerald
dc.contributor.authorUlrich, Rainer G
dc.date.accessioned2021-07-15T20:11:07Z
dc.date.available2021-07-15T20:11:07Z
dc.date.issued2021-06-28
dc.identifier.pmid34203238
dc.identifier.doi10.3390/v13071258
dc.identifier.urihttp://hdl.handle.net/10029/625095
dc.description.abstractThe development of new diagnostic methods resulted in the discovery of novel hepaciviruses in wild populations of the bank vole (Myodes glareolus, syn. Clethrionomys glareolus). The naturally infected voles demonstrate signs of hepatitis similar to those induced by hepatitis C virus (HCV) in humans. The aim of the present research was to investigate the geographical distribution of bank vole-associated hepaciviruses (BvHVs) and their genetic diversity in Europe. Real-time reverse transcription polymerase chain reaction (RT-qPCR) screening revealed BvHV RNA in 442 out of 1838 (24.0%) bank voles from nine European countries and in one of seven northern red-backed voles (Myodes rutilus, syn. Clethrionomys rutilus). BvHV RNA was not found in any other small mammal species (n = 23) tested here. Phylogenetic and isolation-by-distance analyses confirmed the occurrence of both BvHV species (Hepacivirus F and Hepacivirus J) and their sympatric occurrence at several trapping sites in two countries. The broad geographical distribution of BvHVs across Europe was associated with their presence in bank voles of different evolutionary lineages. The extensive geographical distribution and high levels of genetic diversity of BvHVs, as well as the high population fluctuations of bank voles and occasional commensalism in some parts of Europe warrant future studies on the zoonotic potential of BvHVs.en_US
dc.language.isoenen_US
dc.subjectEuropeen_US
dc.subjectHCVen_US
dc.subjectHepacivirus Fen_US
dc.subjectHepacivirus Jen_US
dc.subjectbank vole hepacivirusesen_US
dc.subjectemerging virusen_US
dc.subjectrodent-borne pathogenen_US
dc.titleGeographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe.en_US
dc.typeArticleen_US
dc.identifier.eissn1999-4915
dc.identifier.journalViruses 2021; 13(7):1258en_US
dc.source.journaltitleViruses
dc.source.volume13
dc.source.issue7
dc.source.countrySwitzerland


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