Show simple item record

dc.contributor.authorDuijster, Janneke
dc.contributor.authorMughini-Gras, Lapo
dc.contributor.authorNeefjes, Jacques
dc.contributor.authorFranz, Eelco
dc.date.accessioned2021-09-13T12:43:02Z
dc.date.available2021-09-13T12:43:02Z
dc.date.issued2021-08-10
dc.identifier.pmid34376453
dc.identifier.doi10.1136/bmjopen-2021-050611
dc.identifier.urihttp://hdl.handle.net/10029/625253
dc.description.abstractWhile colon cancer (CC) risk is associated with several lifestyle-related factors, including physical inactivity, smoking and diet, the contribution of occupation to CC morbidity remains largely unclear. Growing evidence indicates that gastrointestinal infections like salmonellosis could contribute to CC development. We performed a nationwide registry study to assess potential associations between occupation (history) and CC, including also those occupations with known increased exposure to gastrointestinal pathogens like Salmonella. METHODS: Person-level occupational data for all residents in The Netherlands were linked to CC diagnosis data. Differences in the incidence of (overall, proximal and distal) CC among occupational sectors and risk groups were tested for significance by calculating standardised incidence ratios (SIRs) with 95% CIs using the general population as reference group. Effects of gender, age, exposure duration and latency were also assessed.en_US
dc.language.isoenen_US
dc.rights© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.subjectepidemiologyen_US
dc.subjectgastrointestinal tumoursen_US
dc.subjectinfectious diseasesen_US
dc.subjectoccupational & industrial medicineen_US
dc.titleOccupational exposure and risk of colon cancer: a nationwide registry study with emphasis on occupational exposure to zoonotic gastrointestinal pathogens.en_US
dc.typeArticleen_US
dc.identifier.eissn2044-6055
dc.identifier.journalBMJ Open 2021; 11(8):e50611en_US
dc.source.journaltitleBMJ open
dc.source.volume11
dc.source.issue8
dc.source.beginpagee050611
dc.source.endpage
dc.source.countryEngland


This item appears in the following Collection(s)

Show simple item record