Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study.
dc.contributor.author | Venekamp, Roderick P | |
dc.contributor.author | Veldhuijzen, Irene K | |
dc.contributor.author | Moons, Karel G M | |
dc.contributor.author | Van den Bijllaardt, Wouter | |
dc.contributor.author | Pas, Suzan D | |
dc.contributor.author | Lodder, Esther B | |
dc.contributor.author | Molenkamp, Richard | |
dc.contributor.author | Igloi, Zsofi | |
dc.contributor.author | Wijers, Constantijn | |
dc.contributor.author | Dos Santos, Claudy Oliveira | |
dc.contributor.author | Debast, Sylvia B | |
dc.contributor.author | Bruins, Marjan J | |
dc.contributor.author | Polad, Khaled | |
dc.contributor.author | Nagel-Imming, Carla R S | |
dc.contributor.author | Han, Wanda G H | |
dc.contributor.author | van de Wijgert, Janneke H H M | |
dc.contributor.author | van den Hof, Susan | |
dc.contributor.author | Schuit, Ewoud | |
dc.date.accessioned | 2022-03-07T15:39:48Z | |
dc.date.available | 2022-03-07T15:39:48Z | |
dc.date.issued | 2022-02-24 | |
dc.identifier.pmid | 35197052 | |
dc.identifier.doi | 10.1186/s12916-022-02300-9 | |
dc.identifier.uri | http://hdl.handle.net/10029/625595 | |
dc.description.abstract | Six thousand nine hundred fifty-five of 7005 participants (99%) with results from both an Ag-RDT and a molecular reference test were analysed. SARS-CoV-2 prevalence and overall sensitivities were 13% (188/1441) and 69% (129/188, 95% CI 62-75) for BD-Veritor, 8% (173/2056) and 69% (119/173, 61-76) for PanBio, and 12% (215/1769) and 74% (160/215, 68-80) for SD-Biosensor with routine sampling and 10% (164/1689) and 75% (123/164, 68-81) for SD-Biosensor with OP-N sampling. In those symptomatic or asymptomatic at sampling, sensitivities were 72-83% and 54-56%, respectively. Above a viral load cut-off (≥5.2 log10 SARS-CoV-2 E-gene copies/mL), sensitivities were 86% (125/146, 79-91) for BD-Veritor, 89% (108/121, 82-94) for PanBio, and 88% (160/182, 82-92) for SD-Biosensor with routine sampling and 84% (118/141, 77-89) with OP-N sampling. Specificities were >99% for all tests in most analyses. Sixty-one per cent of false-negative Ag-RDT participants returned for testing within 14 days (median: 3 days, interquartile range 3) of whom 90% tested positive. | en_US |
dc.language.iso | en | en_US |
dc.rights | © 2022. The Author(s). | |
dc.subject | COVID-19 | en_US |
dc.subject | Diagnostic accuracy | en_US |
dc.subject | Rapid antigen tests | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study. | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 1741-7015 | |
dc.identifier.journal | BMC medicine 2022;20(1):97 | en_US |
dc.source.journaltitle | BMC medicine | |
dc.source.volume | 20 | |
dc.source.issue | 1 | |
dc.source.beginpage | 97 | |
dc.source.endpage | ||
dc.source.country | England |