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dc.contributor.authorChen, Jie
dc.contributor.authorHoek, Gerard
dc.contributor.authorde Hoogh, Kees
dc.contributor.authorRodopoulou, Sophia
dc.contributor.authorAndersen, Zorana J
dc.contributor.authorBellander, Tom
dc.contributor.authorBrandt, Jørgen
dc.contributor.authorFecht, Daniela
dc.contributor.authorForastiere, Francesco
dc.contributor.authorGulliver, John
dc.contributor.authorHertel, Ole
dc.contributor.authorHoffmann, Barbara
dc.contributor.authorHvidtfeldt, Ulla Arthur
dc.contributor.authorVerschuren, W M Monique
dc.contributor.authorJöckel, Karl-Heinz
dc.contributor.authorJørgensen, Jeanette T
dc.contributor.authorKatsouyanni, Klea
dc.contributor.authorKetzel, Matthias
dc.contributor.authorMéndez, Diego Yacamán
dc.contributor.authorLeander, Karin
dc.contributor.authorLiu, Shuo
dc.contributor.authorLjungman, Petter
dc.contributor.authorFaure, Elodie
dc.contributor.authorMagnusson, Patrik K E
dc.contributor.authorNagel, Gabriele
dc.contributor.authorPershagen, Göran
dc.contributor.authorPeters, Annette
dc.contributor.authorRaaschou-Nielsen, Ole
dc.contributor.authorRizzuto, Debora
dc.contributor.authorSamoli, Evangelia
dc.contributor.authorvan der Schouw, Yvonne T
dc.contributor.authorSchramm, Sara
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorStafoggia, Massimo
dc.contributor.authorStrak, Maciej
dc.contributor.authorSørensen, Mette
dc.contributor.authorTjønneland, Anne
dc.contributor.authorWeinmayr, Gudrun
dc.contributor.authorWolf, Kathrin
dc.contributor.authorZitt, Emanuel
dc.contributor.authorBrunekreef, Bert
dc.contributor.authorThurston, George D
dc.date.accessioned2022-06-29T10:29:16Z
dc.date.available2022-06-29T10:29:16Z
dc.date.issued2022-06-23
dc.identifier.pmid35737879
dc.identifier.doi10.1021/acs.est.2c01912
dc.identifier.urihttp://hdl.handle.net/10029/625867
dc.description.abstractWe assessed mortality risks associated with source-specific fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5 identified through a source apportionment analysis. Exposure to 2010 annual average concentrations of source-specific PM2.5 components was assessed at baseline residential addresses. The source apportionment resulted in the identification of five sources: traffic, residual oil combustion, soil, biomass and agriculture, and industry. In single-source analysis, all identified sources were significantly positively associated with increased natural mortality risks. In multisource analysis, associations with all sources attenuated but remained statistically significant with traffic, oil, and biomass and agriculture. The highest association per interquartile increase was observed for the traffic component (HR: 1.06; 95% CI: 1.04 and 1.08 per 2.86 μg/m3 increase) across five identified sources. On a 1 μg/m3 basis, the residual oil-related PM2.5 had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5 mass, suggesting that past estimates using the generic PM2.5 exposure response function have underestimated the potential clean air health benefits of reducing fossil-fuel combustion. Source-specific associations with cause-specific mortality were in general consistent with findings of natural mortality.en_US
dc.language.isoenen_US
dc.subjectabsolute principal component analysis (APCA)en_US
dc.subjectfine particulate matter (PM2.5)en_US
dc.subjectmortalityen_US
dc.subjectsource apportionmenten_US
dc.titleLong-Term Exposure to Source-Specific Fine Particles and Mortality─A Pooled Analysis of 14 European Cohorts within the ELAPSE Project.en_US
dc.typeArticleen_US
dc.identifier.eissn1520-5851
dc.identifier.journalEnvironmental science & technology 2022; 56(13):9277-9290en_US
dc.source.journaltitleEnvironmental science & technology
dc.source.countryUnited States


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