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dc.contributor.authorWagner, Arnika K
dc.contributor.authorKadri, Nadir
dc.contributor.authorTibbitt, Chris
dc.contributor.authorvan de Ven, Koen
dc.contributor.authorBagawath-Singh, Sunitha
dc.contributor.authorOliinyk, Denys
dc.contributor.authorLeGresley, Eric
dc.contributor.authorCampbell, Nicole
dc.contributor.authorTrittel, Stephanie
dc.contributor.authorRiese, Peggy
dc.contributor.authorRibacke, Ulf
dc.contributor.authorSandalova, Tatyana
dc.contributor.authorAchour, Adnane
dc.contributor.authorKärre, Klas
dc.contributor.authorChambers, Benedict J
dc.date.accessioned2022-10-11T07:51:10Z
dc.date.available2022-10-11T07:51:10Z
dc.date.issued2022-09-16
dc.identifier.pmid36185379
dc.identifier.doi10.1016/j.isci.2022.105137
dc.identifier.urihttp://hdl.handle.net/10029/626135
dc.description.abstractAlthough PD-1 was shown to be a hallmark of T cells exhaustion, controversial studies have been reported on the role of PD-1 on NK cells. Here, we found by flow cytometry and single cell RNA sequencing analysis that PD-1 can be expressed on MHC class I-deficient tumor-infiltrating NK cells in vivo. We also demonstrate distinct alterations in the phenotype of PD-1-deficient NK cells and a more mature phenotype which might reduce their capacity to migrate and kill in vivo. Tumor-infiltrating NK cells that express PD-1 were highly associated with the expression of CXCR6. Furthermore, our results demonstrate that PD-L1 molecules in membranes of PD-1-deficient NK cells migrate faster than in NK cells from wild-type mice, suggesting that PD-1 and PD-L1 form cis interactions with each other on NK cells. These data demonstrate that there may be a role for the PD-1/PD-L1 axis in tumor-infiltrating NK cells in vivo.en_US
dc.language.isoenen_US
dc.rights© 2022 The Author(s).
dc.subjectCanceren_US
dc.subjectComponents of the immune systemen_US
dc.subjectImmunologyen_US
dc.subjectTranscriptomicsen_US
dc.titlePD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype.en_US
dc.typeArticleen_US
dc.identifier.eissn2589-0042
dc.identifier.journaliScience 2022;25(10):105137en_US
dc.source.journaltitleiScience
dc.source.volume25
dc.source.issue10
dc.source.beginpage105137
dc.source.endpage
dc.source.countryUnited States


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