Body mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women.
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Authors
Gram, Inger TorhildNorat, Teresa
Rinaldi, Sabina
Dossus, Laure
Lukanova, Annekatrin
Téhard, B
Clavel-Chapelon, Françoise
Gils, C H van
Noord, P A H van
Peeters, Petra H M
Bueno-de-Mesquita, H Bas
Nagel, Gabriele
Linseisen, Jakob
Lahmann, Petra H
Boeing, Heiner
Palli, Domenico
Sacerdote, Carlotta
Panico, Salvatore
Tumino, Rosario
Sieri, Sabina
Dorronsoro Iraeta, Miren
Quirós, José Ramón
Navarro, Carmen A
Barricarte, Aurelio
Tormo, M-J
González, Carlos Alberto
Overvad, Kim
Paaske Johnsen, S
Olsen, Anja
Tjønneland, Anne
Travis, R
Allen, Naomi E
Bingham, Sheila A
Khaw, Kay-Tee
Stattin, P
Trichopoulou, Antonia
Kalapothaki, V
Psaltopoulou, Theodora
Casagrande, Corinne
Riboli, Elio
Kaaks, Rudolf
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ArticleLanguage
en
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Body mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women.Publiekssamenvatting
OBJECTIVE: To examine the relationship between body mass index (BMI) and waist-hip ratio (WHR) with serum levels of insulin-like growth factor-I (IGF-I), and its binding protein (IGFBP)-3. DESIGN: Cross-sectional study on 2139 women participating in a case-control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzyme-linked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3. RESULTS: Adjusted mean serum IGF-I values were lower in women with BMI<22.5 kg/m(2) or BMI>29.2 kg/m(2) compared to women with BMI within this range (P(heterogeneity)<0.0001, P(trend)=0.35). Insulin-like growth factor-I was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (P (trend)=0.005). CONCLUSIONS: Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to non-obese women and inversely related to central adiposity.PMID
16552400ae974a485f413a2113503eed53cd6c53
10.1038/sj.ijo.0803324
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