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    Preclinical and clinical safety studies on DNA vaccines.

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    Authors
    Schalk, Johanna A C
    Mooi, Frits R
    Berbers, Guy A M
    Aerts, Leon A G J M van
    Ovelgönne, Hans
    Kimman, Tjeerd G
    Type
    Article
    Language
    en
    
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    Title
    Preclinical and clinical safety studies on DNA vaccines.
    Publiekssamenvatting
    DNA vaccines are based on the transfer of genetic material, encoding an antigen, to the cells of the vaccine recipient. Despite high expectations of DNA vaccines as a result of promising preclinical data their clinical utility remains unproven. However, much data is gathered in preclinical and clinical studies about the safety of DNA vaccines. Here we review current knowledge about the safety of DNA vaccines. Safety concerns of DNA vaccines relate to genetic, immunologic, toxic, and environmental effects. In this review we provide an overview of findings related to the safety of DNA vaccines, obtained so far. We conclude that the potential risks of DNA vaccines are minimal. However, their safety issues may differ case-by-case, and they should be treated accordingly.
    PMID
    17012886
    URI
    http://hdl.handle.net/10029/6776
    Collections
    Miscellaneous

    entitlement

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