Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.
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Authors
Jakszyn, PaulaBingham, Sheila A
Pera, Guillem
Agudo, Antonio
Luben, Robert
Welch, Ailsa
Boeing, Heiner
Giudice, Giuseppe del
Palli, Domenico
Saieva, Calogero
Krogh, Vittorio
Sacerdote, Carlotta
Tumino, Rosario
Panico, Salvatore
Berglund, Göran
Simán, Henrik
Hallmans, Göran
Sanchez, María José
Larrañaga, Nerea
Barricarte, Aurelio
Chirlaque, María-Dolores
Quirós, José Ramón
Key, Timothy J
Allen, Naomi E
Lund, Eiliv
Carneiro, Fátima
Linseisen, Jakob
Nagel, Gabriele
Overvad, Kim
Tjønneland, Anne
Olsen, Anja
Bueno-de-Mesquita, H Bas
Ocké, Marga C
Peeters, Petra H M
Numans, Mattijs E
Clavel-Chapelon, Françoise
Trichopoulou, Antonia
Fenger, Claus
Stenling, Roger
Ferrari, Pietro
Jenab, Mazda
Norat, Teresa
Riboli, Elio
González, Carlos Alberto
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ArticleLanguage
en
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Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.Publiekssamenvatting
The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 microg on average compared with 93 mug on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 microg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.PMID
16571648ae974a485f413a2113503eed53cd6c53
10.1093/carcin/bgl019
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