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dc.contributor.authorJakszyn, Paula
dc.contributor.authorBingham, Sheila A
dc.contributor.authorPera, Guillem
dc.contributor.authorAgudo, Antonio
dc.contributor.authorLuben, Robert
dc.contributor.authorWelch, Ailsa
dc.contributor.authorBoeing, Heiner
dc.contributor.authorGiudice, Giuseppe del
dc.contributor.authorPalli, Domenico
dc.contributor.authorSaieva, Calogero
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBerglund, Göran
dc.contributor.authorSimán, Henrik
dc.contributor.authorHallmans, Göran
dc.contributor.authorSanchez, María José
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorKey, Timothy J
dc.contributor.authorAllen, Naomi E
dc.contributor.authorLund, Eiliv
dc.contributor.authorCarneiro, Fátima
dc.contributor.authorLinseisen, Jakob
dc.contributor.authorNagel, Gabriele
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorOcké, Marga C
dc.contributor.authorPeeters, Petra H M
dc.contributor.authorNumans, Mattijs E
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorFenger, Claus
dc.contributor.authorStenling, Roger
dc.contributor.authorFerrari, Pietro
dc.contributor.authorJenab, Mazda
dc.contributor.authorNorat, Teresa
dc.contributor.authorRiboli, Elio
dc.contributor.authorGonzález, Carlos Alberto
dc.date.accessioned2007-01-04T09:34:43Z
dc.date.available2007-01-04T09:34:43Z
dc.date.issued2006-07-01
dc.identifier.citationCarcinogenesis 2006, 27(7):1497-501en
dc.identifier.issn0143-3334
dc.identifier.pmid16571648
dc.identifier.doi10.1093/carcin/bgl019
dc.identifier.urihttp://hdl.handle.net/10029/6828
dc.description.abstractThe risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 microg on average compared with 93 mug on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 microg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.
dc.format.extent114539 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleEndogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T14:46:00Z
html.description.abstractThe risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 microg on average compared with 93 mug on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 microg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.


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