Do inhaled carbon nanoparticles translocate directly into the circulation in humans?
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsMills, Nicholas L
Robinson, Simon D
Fuente, Jesus M de la
Cassee, Flemming R
Boon, Nicholas A
Millar, Alistair M
Newby, David E
MetadataShow full item record
TitleDo inhaled carbon nanoparticles translocate directly into the circulation in humans?
PubliekssamenvattingRATIONALE: Increased exposure to particulate air pollution (PM(10)) is a risk factor for death and hospitalization with cardiovascular disease. It has been suggested that the nanoparticulate component of PM(10) is capable of translocating into the circulation with the potential for direct effects on the vasculature. OBJECTIVE: The study's aim was to determine the extent to which inhaled technetium-99m ((99m)Tc)-labeled carbon nanoparticles (Technegas) were able to access the systemic circulation. METHODS AND MAIN RESULTS: Ten healthy volunteers inhaled Technegas and blood samples were taken sequentially over the following 6 h. Technegas particles were 4-20 nm in diameter and aggregated to a median particle diameter of approximately 100 nm. Radioactivity was immediately detected in blood, with levels increasing over 60 min. Thin-layer chromatography of whole blood identified a species that moved with the solvent front, corresponding to unbound (99m)Tc-pertechnetate, which was excreted in urine. There was no evidence of particle-bound (99m)Tc at the origin. gamma Camera images demonstrated high levels of Technegas retention (95.6 +/- 1.7% at 6 h) in the lungs, with no accumulation of radioactivity detected over the liver or spleen. CONCLUSIONS: The majority of (99m)Tc-labeled carbon nanoparticles remain within the lung up to 6 h after inhalation. In contrast to previous published studies, thin-layer chromatography did not support the hypothesis that inhaled Technegas carbon nanoparticles pass directly from the lungs into the systemic circulation.
- Passage of inhaled particles into the blood circulation in humans.
- Authors: Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, Vanbilloen H, Mortelmans L, Nemery B
- Issue date: 2002 Jan 29
- Development of a physiologically based kinetic model for 99m-technetium-labelled carbon nanoparticles inhaled by humans.
- Authors: Péry AR, Brochot C, Hoet PH, Nemmar A, Bois FY
- Issue date: 2009 Nov
- Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery.
- Authors: Möller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Häussinger K, Kreyling WG
- Issue date: 2008 Feb 15
- Effects of ambient air particulate exposure on blood-gas barrier permeability and lung function.
- Authors: Bräuner EV, Mortensen J, Møller P, Bernard A, Vinzents P, Wåhlin P, Glasius M, Loft S
- Issue date: 2009 Jan
- Effects of concentrated ambient particles on normal and hypersecretory airways in rats.
- Authors: Harkema JR, Keeler G, Wagner J, Morishita M, Timm E, Hotchkiss J, Marsik F, Dvonch T, Kaminski N, Barr E
- Issue date: 2004 Aug