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    Probiotics: immunomodulation and evaluation of safety and efficacy.

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    Authors
    Ezendam, Janine
    Loveren, Henk van
    Type
    Article
    Language
    en
    
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    Title
    Probiotics: immunomodulation and evaluation of safety and efficacy.
    Publiekssamenvatting
    The intake of probiotics has been associated with beneficial effects on the immune system, such as improved disease resistance and diminished risk of allergies. This review gives an overview of the immunomodulatory effects of probiotics investigated with in vitro assays, experimental animal models, and clinical trials, and explores possible mechanisms underlying the immunomodulatory effects. Immunomodulation, however, is not always beneficial and might induce detrimental effects; therefore, a scheme is proposed for benefit-risk assessment of immunomodulation by probiotics. Within this scheme, expert judgment based on data derived from a panel of in vitro assays, animal models, and clinical trials should lead to conclusions on efficacy and safety aspects of probiotics.
    PMID
    16491665
    URI
    http://hdl.handle.net/10029/7043
    Collections
    Miscellaneous

    entitlement

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