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dc.contributor.authorEzendam, Janine
dc.contributor.authorLoveren, Henk van
dc.date.accessioned2007-01-09T11:43:14Z
dc.date.available2007-01-09T11:43:14Z
dc.date.issued2006-01-01
dc.identifier.citationNutr. Rev. 2006, 64(1):1-14en
dc.identifier.issn0029-6643
dc.identifier.pmid16491665
dc.identifier.urihttp://hdl.handle.net/10029/7043
dc.description.abstractThe intake of probiotics has been associated with beneficial effects on the immune system, such as improved disease resistance and diminished risk of allergies. This review gives an overview of the immunomodulatory effects of probiotics investigated with in vitro assays, experimental animal models, and clinical trials, and explores possible mechanisms underlying the immunomodulatory effects. Immunomodulation, however, is not always beneficial and might induce detrimental effects; therefore, a scheme is proposed for benefit-risk assessment of immunomodulation by probiotics. Within this scheme, expert judgment based on data derived from a panel of in vitro assays, animal models, and clinical trials should lead to conclusions on efficacy and safety aspects of probiotics.
dc.format.extent741019 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleProbiotics: immunomodulation and evaluation of safety and efficacy.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T11:36:02Z
html.description.abstractThe intake of probiotics has been associated with beneficial effects on the immune system, such as improved disease resistance and diminished risk of allergies. This review gives an overview of the immunomodulatory effects of probiotics investigated with in vitro assays, experimental animal models, and clinical trials, and explores possible mechanisms underlying the immunomodulatory effects. Immunomodulation, however, is not always beneficial and might induce detrimental effects; therefore, a scheme is proposed for benefit-risk assessment of immunomodulation by probiotics. Within this scheme, expert judgment based on data derived from a panel of in vitro assays, animal models, and clinical trials should lead to conclusions on efficacy and safety aspects of probiotics.


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