Relation between sources of particulate air pollution and biological effect parameters in samples from four European cities: an exploratory study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsSteerenberg, Peter A
Amelsvoort, Ludo van
Hetland, Ragna B
Bloemen, Henk J T
Cassee, Flemming R
MetadataShow full item record
TitleRelation between sources of particulate air pollution and biological effect parameters in samples from four European cities: an exploratory study.
PubliekssamenvattingGiven that there are widely different prevalence rates of respiratory allergies and asthma between the countries of Europe and that exposure to ambient particulate matter (PM) is substantial in urban environments throughout Europe, an EU project entitled "Respiratory Allergy and Inflammation Due to Ambient Particles" (RAIAP) was set up. The project focused on the role of physical and chemical composition of PM on release of cytokines of cells in vitro, on respiratory inflammation in vivo, and on adjuvant potency in allergy animal models. Coarse (2.5-10 microm) and fine (0.15-2.5 microm) particles were collected during the spring, summer and winter in Rome (I), Oslo (N), Lodz (PL), and Amsterdam (NL). Markers within the same model were often well correlated. Markers of inflammation in the in vitro and in vivo models also showed a high degree of correlation. In contrast, correlation between parameters in the different allergy models and between allergy and inflammation markers was generally poor. This suggests that various bioassays are needed to assess the potential hazard of PM. The present study also showed that by clustering chemical constituents of PM based on the overall response pattern in the bioassays, five distinct groups could be identified. The clusters of traffic, industrial combustion and/or incinerators (TICI), and combustion of black and brown coal/wood smoke (BBCW) were associated primarily with adjuvant activity for respiratory allergy, whereas clusters of crustal of material (CM) and sea spray (SS) are predominantly associated with measures for inflammation and acute toxicity. The cluster of secondary inorganic aerosol and long-range transport aerosol (SIALT) was exclusive associated with systemic allergy. The present study has shown that biological effect of PM can be linked to one or more PM emission sources and that this linkage requires a wide range of bioassays.
- Fine ambient particles from various sites in europe exerted a greater IgE adjuvant effect than coarse ambient particles in a mouse model.
- Authors: Alberg T, Cassee FR, Groeng EC, Dybing E, Løvik M
- Issue date: 2009
- Adjuvant activity of ambient particulate matter of different sites, sizes, and seasons in a respiratory allergy mouse model.
- Authors: Steerenberg PA, Withagen CE, van Dalen WJ, Dormans JA, Cassee FR, Heisterkamp SH, van Loveren H
- Issue date: 2004 Nov 1
- Dose dependency of adjuvant activity of particulate matter from five European sites in three seasons in an ovalbumin-mouse model.
- Authors: Steerenberg PA, Withagen CE, van Dalen WJ, Dormans JA, Heisterkamp SH, van Loveren H, Cassee FR
- Issue date: 2005 Mar
- Ambient air particles from four European cities increase the primary cellular response to allergen in the draining lymph node.
- Authors: Nygaard UC, Alberg T, Bleumink R, Aase A, Dybing E, Pieters R, Løvik M
- Issue date: 2005 Feb 14
- Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples from contrasting air pollution in Europe.
- Authors: Happo MS, Hirvonen MR, Halinen AI, Jalava PI, Pennanen AS, Sillanpaa M, Hillamo R, Salonen RO
- Issue date: 2008 Nov