Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
TitleEffects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish.
PubliekssamenvattingSome ubiquitous pollutants of the aquatic environment, such as PCBs or other polyhalogenated aromatic hydrocarbons, may disrupt the thyroid hormone system. In a partial life cycle assay with zebrafish (Danio rerio), we studied the effects of the reference compound propylthiouracil (PTU) on reproduction, growth and development, histopathology of some target tissues, and plasma thyroid hormone levels. PTU induced a concentration-dependent increase of egg production with a concomitant decrease of mature oocyte size but had no effect on fertilization rate or hatching. In F1, serious dysmorphogenesis was found in 4 dph larvae at the highest PTU level tested (100 mg/L), and there was a dose-dependent decrease in body length and weight at 42 dph (significant at 100 mg/L PTU). At this time, there was also a decreased scale thickness, suggesting inhibited metamorphosis, detectable at 1 mg/L PTU and higher. PTU also induced activation of the thyroid follicles in a concentration-dependent way, in juveniles associated with hyperemia in the thyroid area, and depletion of liver glycogen. Effects in adults were associated with decreased circulating levels of the thyroid hormones T3 and T4. These observations indicate that disruption of the thyroid hormone system may affect the fitness of these aquatic organisms. The zebrafish model may contribute to the identification of thyroid hormone disrupting activity in water samples and also in the interpretation of histological observations in free-ranging fish species.
- Detection of thyroid toxicants in a tier I screening battery and alterations in thyroid endpoints over 28 days of exposure.
- Authors: O'Connor JC, Frame SR, Davis LG, Cook JC
- Issue date: 1999 Sep
- Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine.
- Authors: Degitz SJ, Holcombe GW, Flynn KM, Kosian PA, Korte JJ, Tietge JE
- Issue date: 2005 Oct
- Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions.
- Authors: Baumann L, Ros A, Rehberger K, Neuhauss SC, Segner H
- Issue date: 2016 Mar
- Effects of the anti-thyroidal compound potassium-perchlorate on the thyroid system of the zebrafish.
- Authors: Schmidt F, Schnurr S, Wolf R, Braunbeck T
- Issue date: 2012 Mar
- Ultrastructural Alterations in Thyrocytes of Zebrafish ( Danio rerio) after Exposure to Propylthiouracil and Perchlorate.
- Authors: Schmidt F, Wolf R, Baumann L, Braunbeck T
- Issue date: 2017 Jul