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dc.contributor.authorCanzian, F
dc.contributor.authorMcKay, J D
dc.contributor.authorCleveland, R J
dc.contributor.authorDossus, Laure
dc.contributor.authorBiessy, Carine
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorLandi, S
dc.contributor.authorBoillot, C
dc.contributor.authorMonnier, S
dc.contributor.authorChajès, V
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorTéhard, B
dc.contributor.authorChang-Claude, J
dc.contributor.authorLinseisen, Jakob
dc.contributor.authorLahmann, Petra H
dc.contributor.authorPischon, Tobias
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorZilis, D
dc.contributor.authorPalli, Domenico
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorBerrino, Franco
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorGils, C H van
dc.contributor.authorPeeters, Petra H M
dc.contributor.authorPera, Guillem
dc.contributor.authorArdanaz, Eva
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorMartínez-García, Carmen
dc.contributor.authorAllen, Naomi E
dc.contributor.authorKey, Timothy J
dc.contributor.authorBingham, Sheila A
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorSlimani, N
dc.contributor.authorNorat, Teresa
dc.contributor.authorRiboli, Elio
dc.contributor.authorKaaks, Rudolf
dc.date.accessioned2007-01-09T15:24:58Z
dc.date.available2007-01-09T15:24:58Z
dc.date.issued2006-01-30
dc.identifier.citationBr. J. Cancer 2006, 94(2):299-307en
dc.identifier.issn0007-0920
dc.identifier.pmid16404426
dc.identifier.doi10.1038/sj.bjc.6602936
dc.identifier.urihttp://hdl.handle.net/10029/7096
dc.description.abstractInsulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-I is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins (IGFBPs), among which the most important are IGFBP-3 and IGFBP-1. Polymorphisms of the IGF1 gene and of genes encoding for the major IGF-I carriers may predict circulating levels of IGF-I and have an impact on cancer risk. We tested this hypothesis with a case-control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1, IGFBP3 and IGFALS, and measured serum levels of IGF-I and IGFBP-3 in samples of cases and controls. We found a weak but significant association of polymorphisms at the 5' end of the IGF1 gene with breast cancer risk, particularly among women younger than 55 years, and a strong association of polymorphisms located in the 5' end of IGFBP3 with circulating levels of IGFBP-3, which confirms previous findings. Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians.
dc.format.extent286954 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titlePolymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T11:43:33Z
html.description.abstractInsulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-I is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins (IGFBPs), among which the most important are IGFBP-3 and IGFBP-1. Polymorphisms of the IGF1 gene and of genes encoding for the major IGF-I carriers may predict circulating levels of IGF-I and have an impact on cancer risk. We tested this hypothesis with a case-control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1, IGFBP3 and IGFALS, and measured serum levels of IGF-I and IGFBP-3 in samples of cases and controls. We found a weak but significant association of polymorphisms at the 5' end of the IGF1 gene with breast cancer risk, particularly among women younger than 55 years, and a strong association of polymorphisms located in the 5' end of IGFBP3 with circulating levels of IGFBP-3, which confirms previous findings. Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians.


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