Variable host-pathogen compatibility in Mycobacterium tuberculosis.
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Authors
Gagneux, SebastienDeRiemer, Kathryn
Van, Tran
Kato-Maeda, Midori
Jong, Bouke C de
Narayanan, Sujatha
Nicol, Mark
Niemann, Stefan
Kremer, Kristin
Gutierrez, M Cristina
Hilty, Markus
Hopewell, Philip C
Small, Peter M
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ArticleLanguage
en
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Variable host-pathogen compatibility in Mycobacterium tuberculosis.Publiekssamenvatting
Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations. In an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatric than in allopatric patient populations. Tuberculosis cases that did occur in allopatric hosts disproportionately involved high-risk individuals with impaired host resistance. These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development.PMID
16477032ae974a485f413a2113503eed53cd6c53
10.1073/pnas.0511240103
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