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    Variable host-pathogen compatibility in Mycobacterium tuberculosis.

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    Authors
    Gagneux, Sebastien
    DeRiemer, Kathryn
    Van, Tran
    Kato-Maeda, Midori
    Jong, Bouke C de
    Narayanan, Sujatha
    Nicol, Mark
    Niemann, Stefan
    Kremer, Kristin
    Gutierrez, M Cristina
    Hilty, Markus
    Hopewell, Philip C
    Small, Peter M
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    Type
    Article
    Language
    en
    
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    Title
    Variable host-pathogen compatibility in Mycobacterium tuberculosis.
    Publiekssamenvatting
    Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations. In an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatric than in allopatric patient populations. Tuberculosis cases that did occur in allopatric hosts disproportionately involved high-risk individuals with impaired host resistance. These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development.
    DOI
    10.1073/pnas.0511240103
    PMID
    16477032
    URI
    http://hdl.handle.net/10029/7140
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.0511240103
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