Variable host-pathogen compatibility in Mycobacterium tuberculosis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Jong, Bouke C de
Gutierrez, M Cristina
Hopewell, Philip C
Small, Peter M
MetadataShow full item record
TitleVariable host-pathogen compatibility in Mycobacterium tuberculosis.
PubliekssamenvattingMycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations. In an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatric than in allopatric patient populations. Tuberculosis cases that did occur in allopatric hosts disproportionately involved high-risk individuals with impaired host resistance. These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development.
- Genetic geography of Mycobacterium tuberculosis Beijing genotype: a multifacet mirror of human history?
- Authors: Mokrousov I
- Issue date: 2008 Dec
- Dissemination of Mycobacterium tuberculosis across the San Francisco Bay Area.
- Authors: Bradford WZ, Koehler J, El-Hajj H, Hopewell PC, Reingold AL, Agasino CB, Cave MD, Rane S, Yang Z, Crane CM, Small PM
- Issue date: 1998 Apr
- [Development of antituberculous drugs: current status and future prospects].
- Authors: Tomioka H, Namba K
- Issue date: 2006 Dec
- HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis.
- Authors: Fenner L, Egger M, Bodmer T, Furrer H, Ballif M, Battegay M, Helbling P, Fehr J, Gsponer T, Rieder HL, Zwahlen M, Hoffmann M, Bernasconi E, Cavassini M, Calmy A, Dolina M, Frei R, Janssens JP, Borrell S, Stucki D, Schrenzel J, Böttger EC, Gagneux S, Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups
- Issue date: 2013
- Allopatric tuberculosis host-pathogen relationships are associated with greater pulmonary impairment.
- Authors: Pasipanodya JG, Moonan PK, Vecino E, Miller TL, Fernandez M, Slocum P, Drewyer G, Weis SE
- Issue date: 2013 Jun