Show simple item record

dc.contributor.authorGagneux, Sebastien
dc.contributor.authorDeRiemer, Kathryn
dc.contributor.authorVan, Tran
dc.contributor.authorKato-Maeda, Midori
dc.contributor.authorJong, Bouke C de
dc.contributor.authorNarayanan, Sujatha
dc.contributor.authorNicol, Mark
dc.contributor.authorNiemann, Stefan
dc.contributor.authorKremer, Kristin
dc.contributor.authorGutierrez, M Cristina
dc.contributor.authorHilty, Markus
dc.contributor.authorHopewell, Philip C
dc.contributor.authorSmall, Peter M
dc.date.accessioned2007-01-10T09:00:16Z
dc.date.available2007-01-10T09:00:16Z
dc.date.issued2006-02-21
dc.identifier.citationProc. Natl. Acad. Sci. U.S.A. 2006, 103(8):2869-73en
dc.identifier.issn0027-8424
dc.identifier.pmid16477032
dc.identifier.doi10.1073/pnas.0511240103
dc.identifier.urihttp://hdl.handle.net/10029/7140
dc.description.abstractMycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations. In an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatric than in allopatric patient populations. Tuberculosis cases that did occur in allopatric hosts disproportionately involved high-risk individuals with impaired host resistance. These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development.
dc.format.extent455998 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleVariable host-pathogen compatibility in Mycobacterium tuberculosis.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T11:45:39Z
html.description.abstractMycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations. In an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatric than in allopatric patient populations. Tuberculosis cases that did occur in allopatric hosts disproportionately involved high-risk individuals with impaired host resistance. These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development.


Files in this item

Thumbnail
Name:
gagneux.pdf
Size:
445.3Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record