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dc.contributor.authorRinaldi, Sabina
dc.contributor.authorKey, Timothy J
dc.contributor.authorPeeters, Petra H M
dc.contributor.authorLahmann, Petra H
dc.contributor.authorLukanova, Annekatrin
dc.contributor.authorDossus, Laure
dc.contributor.authorBiessy, Carine
dc.contributor.authorVineis, Paolo
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorBerrino, Franco
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorPalli, Domenico
dc.contributor.authorNagel, Gabriele
dc.contributor.authorLinseisen, Jakob
dc.contributor.authorBoeing, Heiner
dc.contributor.authorRoddam, Andrew
dc.contributor.authorBingham, Sheila A
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorChloptios, John
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorTehard, Bertrand
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorGonzález, Carlos Alberto
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorMartinez, Carmen
dc.contributor.authorMonninkhof, Evelyn
dc.contributor.authorGrobbee, Diederick E
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorFerrari, Pietro
dc.contributor.authorSlimani, Nadia
dc.contributor.authorRiboli, Elio
dc.contributor.authorKaaks, Rudolf
dc.date.accessioned2007-01-10T10:39:22Z
dc.date.available2007-01-10T10:39:22Z
dc.date.issued2006-06-01
dc.identifier.citationInt. J. Cancer 2006, 118(11):2832-9en
dc.identifier.issn0020-7136
dc.identifier.pmid16385576
dc.identifier.doi10.1002/ijc.21730
dc.identifier.urihttp://hdl.handle.net/10029/7148
dc.description.abstractIn a large case-control study on breast cancer risk and serum hormone concentrations, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we examined to what extent the relationship of excess body weight with breast cancer risk may be explained by changes in sex steroids. Height, weight, waist and hip circumferences, and serum measurements of testosterone [T], androstenedione [Delta4], dehydroepiandrosterone sulphate [DHEAS], estradiol [E2], estrone [E1] and sex-hormone binding globulin [SHBG] were available for 613 breast cancer cases, and 1,139 matched controls, who were all menopausal at the time of blood donation. Free T [fT] and free E2 [fE2] were calculated using mass action equations. Breast cancer risk was related to body mass index (BMI) (RR = 1.11 [0.99-1.25], per 5 kg/m2 increase in BMI), and waist (RR = 1.12 [1.02-1.24], per 10 cm increase) and hip circumferences (RR = 1.14 [1.02-1.27], per 10 cm increase). The increase in breast cancer risk associated with adiposity was substantially reduced after adjustment for any estrogens, especially for fE2 (from 1.11 [0.99-1.25] to 0.99 [0.87-1.12], from 1.12 [1.02-1.24] to 1.02 [0.92-1.14] and from 1.14 [1.02-1.27] to 1.05 [0.93-1.18] for BMI, waist and hip circumferences, respectively). A modest attenuation in excess risk was observed after adjustment for fT, but the remaining androgens had little effect on the association of body adiposity with breast cancer. Our data indicate that the relationship of adiposity with breast cancer in postmenopausal women could be partially explained by the increases in endogenous estrogens, and by a decrease in levels of SHBG.
dc.format.extent212061 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleAnthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T11:48:25Z
html.description.abstractIn a large case-control study on breast cancer risk and serum hormone concentrations, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we examined to what extent the relationship of excess body weight with breast cancer risk may be explained by changes in sex steroids. Height, weight, waist and hip circumferences, and serum measurements of testosterone [T], androstenedione [Delta4], dehydroepiandrosterone sulphate [DHEAS], estradiol [E2], estrone [E1] and sex-hormone binding globulin [SHBG] were available for 613 breast cancer cases, and 1,139 matched controls, who were all menopausal at the time of blood donation. Free T [fT] and free E2 [fE2] were calculated using mass action equations. Breast cancer risk was related to body mass index (BMI) (RR = 1.11 [0.99-1.25], per 5 kg/m2 increase in BMI), and waist (RR = 1.12 [1.02-1.24], per 10 cm increase) and hip circumferences (RR = 1.14 [1.02-1.27], per 10 cm increase). The increase in breast cancer risk associated with adiposity was substantially reduced after adjustment for any estrogens, especially for fE2 (from 1.11 [0.99-1.25] to 0.99 [0.87-1.12], from 1.12 [1.02-1.24] to 1.02 [0.92-1.14] and from 1.14 [1.02-1.27] to 1.05 [0.93-1.18] for BMI, waist and hip circumferences, respectively). A modest attenuation in excess risk was observed after adjustment for fT, but the remaining androgens had little effect on the association of body adiposity with breast cancer. Our data indicate that the relationship of adiposity with breast cancer in postmenopausal women could be partially explained by the increases in endogenous estrogens, and by a decrease in levels of SHBG.


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