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dc.contributor.authorVredenbregt, M J
dc.contributor.authorBlok-Tip, L
dc.contributor.authorHoogerbrugge, Ronald
dc.contributor.authorBarends, D M
dc.contributor.authorKaste, D de
dc.date.accessioned2007-01-10T11:49:22Z
dc.date.available2007-01-10T11:49:22Z
dc.date.issued2006-03-03
dc.identifier.citationJ Pharm Biomed Anal 2006, 40(4):840-9en
dc.identifier.issn0731-7085
dc.identifier.pmid16229983
dc.identifier.doi10.1016/j.jpba.2005.07.048
dc.identifier.urihttp://hdl.handle.net/10029/7171
dc.description.abstractWe describe a near-infrared spectroscopy (NIRS) method for fast-screening Viagra tablets, counterfeit Viagra tablets, and imitations of Viagra. The method can (1) check the homogeneity of a batch; (2) distinguish counterfeits and imitations from authentic Viagra; (3) screen for the presence of sildenafil citrate, the pharmacologically active substance in Viagra, irrespectively of the excipients present; (4) and detect whether similar samples have been previously analysed. We applied the method to 103 samples with a diversity of appearance, chemical composition, and origin. Other analytical methods confirmed the positive screening results for sildenafil citrate and the presence of other pharmacological active substances. The NIRS screening indicated the absence of sildenafil citrate in the presence of another pharmacological substance for only 2 samples, where the reference methods showed the presence of sildenafil citrate in addition to that of clomifene citrate. Otherwise, the method gave no false positive or negative results. The NIRS screening method is very fast and reliable for detecting counterfeits and imitations, and it correctly predicts the presence or absence of sildenafil citrate in 98% of the samples.
dc.format.extent793999 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleScreening suspected counterfeit Viagra and imitations of Viagra with near-infrared spectroscopy.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T14:53:47Z
html.description.abstractWe describe a near-infrared spectroscopy (NIRS) method for fast-screening Viagra tablets, counterfeit Viagra tablets, and imitations of Viagra. The method can (1) check the homogeneity of a batch; (2) distinguish counterfeits and imitations from authentic Viagra; (3) screen for the presence of sildenafil citrate, the pharmacologically active substance in Viagra, irrespectively of the excipients present; (4) and detect whether similar samples have been previously analysed. We applied the method to 103 samples with a diversity of appearance, chemical composition, and origin. Other analytical methods confirmed the positive screening results for sildenafil citrate and the presence of other pharmacological active substances. The NIRS screening indicated the absence of sildenafil citrate in the presence of another pharmacological substance for only 2 samples, where the reference methods showed the presence of sildenafil citrate in addition to that of clomifene citrate. Otherwise, the method gave no false positive or negative results. The NIRS screening method is very fast and reliable for detecting counterfeits and imitations, and it correctly predicts the presence or absence of sildenafil citrate in 98% of the samples.


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