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    Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains.

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    Authors
    Sabat, Artur
    Melles, Damian C
    Martirosian, Gayane
    Grundmann, Hajo
    Belkum, Alex van
    Hryniewicz, Waleria
    Type
    Article
    Language
    en
    
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    Title
    Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains.
    Publiekssamenvatting
    The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection.
    DOI
    10.1128/JCM.44.3.1135-1138.2006
    PMID
    16517913
    URI
    http://hdl.handle.net/10029/7189
    ae974a485f413a2113503eed53cd6c53
    10.1128/JCM.44.3.1135-1138.2006
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