Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains
dc.contributor.author | Sabat, Artur | |
dc.contributor.author | Melles, Damian C | |
dc.contributor.author | Martirosian, Gayane | |
dc.contributor.author | Grundmann, Hajo | |
dc.contributor.author | van Belkum, Alex | |
dc.contributor.author | Hryniewicz, Waleria | |
dc.date.accessioned | 2007-01-10T12:58:26Z | |
dc.date.available | 2007-01-10T12:58:26Z | |
dc.date.issued | 2006-03-01 | |
dc.identifier.citation | J. Clin. Microbiol. 2006, 44(3):1135-8 | en |
dc.identifier.issn | 0095-1137 | |
dc.identifier.pmid | 16517913 | |
dc.identifier.doi | 10.1128/JCM.44.3.1135-1138.2006 | |
dc.identifier.uri | http://hdl.handle.net/10029/7189 | |
dc.description.abstract | The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection. | |
dc.format.extent | 90429 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.title | Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains | en |
dc.type | Article | en |
dc.format.dig | YES | |
refterms.dateFOA | 2018-12-18T14:54:10Z | |
html.description.abstract | The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection. |