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AuthorsSmith, Noel H
Driscoll, Jeffrey R
Gordon, Stephen V
Soolingen, Dick van
Hewinson, R Glyn
Smith, John Maynard
MetadataShow full item record
TitleEcotypes of the Mycobacterium tuberculosis complex.
PubliekssamenvattingA phylogeny of the Mycobacterium tuberculosis complex has recently shown that the animal-adapted strains are found in a single lineage marked by the deletion of chromosomal region 9 (RD9) [Brosch et al., 2002. A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc. Natl Acad. Sci. USA 99 (6), 3684-3689]. We have obtained the spoligotype patterns of the RD9 deleted strains used to generate this new evolutionary scenario and we show that the presence of spoligotype spacers 3, 9, 16, 39, and 40-43 is phylogenetically informative in this lineage. We have used the phylogenetically informative spoligotype spacers to screen a database of spoligotype patterns and have identified further members of a group of strains apparently host-adapted to antelopes. The presence of the spoligotype spacers is congruent with the phylogeny generated by chromosomal deletions, suggesting that recombination is rare or absent between strains of this lineage. The phylogenetically informative spacers, in concert with the previously identified single nucleotide mutations and chromosomal deletions, can be used to identify a series of clades in the RD9 deleted lineage each with a separate host preference. Finally, we discuss the application of the ecotype concept to this series of clades and suggest that the M. tuberculosis complex may best be described as a series of host-adapted ecotypes.
- Naming spoligotype patterns for the RD9-deleted lineage of the Mycobacterium tuberculosis complex; www.Mbovis.org.
- Authors: Smith NH, Upton P
- Issue date: 2012 Jun
- Evolutionary pathway of the Beijing lineage of Mycobacterium tuberculosis based on genomic deletions and mutT genes polymorphisms.
- Authors: Rindi L, Lari N, Cuccu B, Garzelli C
- Issue date: 2009 Jan
- Single nucleotide polymorphisms in cell wall biosynthesis-associated genes and phylogeny of Mycobacterium tuberculosis lineages.
- Authors: Chuang PC, Chen YM, Chen HY, Jou R
- Issue date: 2010 May
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- Authors: Brosch R, Gordon SV, Marmiesse M, Brodin P, Buchrieser C, Eiglmeier K, Garnier T, Gutierrez C, Hewinson G, Kremer K, Parsons LM, Pym AS, Samper S, van Soolingen D, Cole ST
- Issue date: 2002 Mar 19
- Infection of African buffalo (Syncerus caffer) by oryx bacillus, a rare member of the antelope clade of the Mycobacterium tuberculosis complex.
- Authors: Gey van Pittius NC, Perrett KD, Michel AL, Keet DF, Hlokwe T, Streicher EM, Warren RM, van Helden PD
- Issue date: 2012 Oct