Anthropometry, physical activity, and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition.
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Authors
Berrington de González, AmySpencer, Elizabeth A
Bueno-de-Mesquita, H Bas
Roddam, Andrew
Stolzenberg-Solomon, Rachel
Halkjaer, Jytte
Tjønneland, Anne
Overvad, Kim
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine
Boeing, Heiner
Pischon, Tobias
Linseisen, Jakob
Rohrmann, Sabine
Trichopoulou, Antonia
Benetou, Vassiliki
Papadimitriou, Aristoteles
Pala, Valeria
Palli, Domenico
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Boshuizen, Hendriek C
Ocké, Marga C
Peeters, Petra H
Lund, Eiliv
Gonzalez, Carlos A
Larrañaga, Nerea
Martinez-Garcia, Carmen
Mendez, Michelle
Navarro, Carmen
Quirós, J Ramón
Tormo, María-José
Hallmans, Göran
Ye, Weimin
Bingham, Sheila A
Khaw, Kay-Tee
Allen, Naomi
Key, Tim J
Jenab, Mazda
Norat, Teresa
Ferrari, Pietro
Riboli, Elio
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ArticleLanguage
en
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Anthropometry, physical activity, and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition.Publiekssamenvatting
Tobacco smoking is the only established risk factor for pancreatic cancer. Results from several epidemiologic studies have suggested that increased body mass index and/or lack of physical activity may be associated with an increased risk of this disease. We examined the relationship between anthropometry and physical activity recorded at baseline and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (n = 438,405 males and females age 19-84 years and followed for a total of 2,826,070 person-years). Relative risks (RR) were calculated using Cox proportional hazards models stratified by age, sex, and country and adjusted for smoking and self-reported diabetes and, where appropriate, height. In total, there were 324 incident cases of pancreatic cancer diagnosed in the cohort over an average of 6 years of follow-up. There was evidence that the RR of pancreatic cancer was associated with increased height [RR, 1.74; 95% confidence interval (95% CI), 1.20-2.52] for highest quartile compared with lowest quartile (P(trend) = 0.001). However, this trend was primarily due to a low risk in the lowest quartile, as when this group was excluded, the trend was no longer statistically significant (P = 0.27). A larger waist-to-hip ratio and waist circumference were both associated with an increased risk of developing the disease (RR per 0.1, 1.24; 95% CI, 1.04-1.48; P(trend) = 0.02 and RR per 10 cm, 1.13; 95% CI, 1.01-1.26; P(trend) = 0.03, respectively). There was a nonsignificant increased risk of pancreatic cancer with increasing body mass index (RR, 1.09; 95% CI, 0.95-1.24 per 5 kg/m(2)), and a nonsignificant decreased risk with total physical activity (RR, 0.82; 95% CI, 0.50-1.35 for most active versus inactive). Future studies should consider including measurements of waist and hip circumference, to further investigate the relationship between central adiposity and the risk of pancreatic cancer.PMID
16702364ae974a485f413a2113503eed53cd6c53
10.1158/1055-9965.EPI-05-0800
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