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dc.contributor.authorBerrington de González, Amy
dc.contributor.authorSpencer, Elizabeth A
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorRoddam, Andrew
dc.contributor.authorStolzenberg-Solomon, Rachel
dc.contributor.authorHalkjaer, Jytte
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorClavel-Chapelon, Francoise
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorBoeing, Heiner
dc.contributor.authorPischon, Tobias
dc.contributor.authorLinseisen, Jakob
dc.contributor.authorRohrmann, Sabine
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBenetou, Vassiliki
dc.contributor.authorPapadimitriou, Aristoteles
dc.contributor.authorPala, Valeria
dc.contributor.authorPalli, Domenico
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorBoshuizen, Hendriek C
dc.contributor.authorOcké, Marga C
dc.contributor.authorPeeters, Petra H
dc.contributor.authorLund, Eiliv
dc.contributor.authorGonzalez, Carlos A
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorMartinez-Garcia, Carmen
dc.contributor.authorMendez, Michelle
dc.contributor.authorNavarro, Carmen
dc.contributor.authorQuirós, J Ramón
dc.contributor.authorTormo, María-José
dc.contributor.authorHallmans, Göran
dc.contributor.authorYe, Weimin
dc.contributor.authorBingham, Sheila A
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorAllen, Naomi
dc.contributor.authorKey, Tim J
dc.contributor.authorJenab, Mazda
dc.contributor.authorNorat, Teresa
dc.contributor.authorFerrari, Pietro
dc.contributor.authorRiboli, Elio
dc.date.accessioned2007-01-18T08:57:21Z
dc.date.available2007-01-18T08:57:21Z
dc.date.issued2006-05-01
dc.identifier.citationCancer Epidemiol. Biomarkers Prev. 2006, 15(5):879-85en
dc.identifier.issn1055-9965
dc.identifier.pmid16702364
dc.identifier.doi10.1158/1055-9965.EPI-05-0800
dc.identifier.urihttp://hdl.handle.net/10029/7604
dc.description.abstractTobacco smoking is the only established risk factor for pancreatic cancer. Results from several epidemiologic studies have suggested that increased body mass index and/or lack of physical activity may be associated with an increased risk of this disease. We examined the relationship between anthropometry and physical activity recorded at baseline and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (n = 438,405 males and females age 19-84 years and followed for a total of 2,826,070 person-years). Relative risks (RR) were calculated using Cox proportional hazards models stratified by age, sex, and country and adjusted for smoking and self-reported diabetes and, where appropriate, height. In total, there were 324 incident cases of pancreatic cancer diagnosed in the cohort over an average of 6 years of follow-up. There was evidence that the RR of pancreatic cancer was associated with increased height [RR, 1.74; 95% confidence interval (95% CI), 1.20-2.52] for highest quartile compared with lowest quartile (P(trend) = 0.001). However, this trend was primarily due to a low risk in the lowest quartile, as when this group was excluded, the trend was no longer statistically significant (P = 0.27). A larger waist-to-hip ratio and waist circumference were both associated with an increased risk of developing the disease (RR per 0.1, 1.24; 95% CI, 1.04-1.48; P(trend) = 0.02 and RR per 10 cm, 1.13; 95% CI, 1.01-1.26; P(trend) = 0.03, respectively). There was a nonsignificant increased risk of pancreatic cancer with increasing body mass index (RR, 1.09; 95% CI, 0.95-1.24 per 5 kg/m(2)), and a nonsignificant decreased risk with total physical activity (RR, 0.82; 95% CI, 0.50-1.35 for most active versus inactive). Future studies should consider including measurements of waist and hip circumference, to further investigate the relationship between central adiposity and the risk of pancreatic cancer.
dc.format.extent168064 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleAnthropometry, physical activity, and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T15:32:48Z
html.description.abstractTobacco smoking is the only established risk factor for pancreatic cancer. Results from several epidemiologic studies have suggested that increased body mass index and/or lack of physical activity may be associated with an increased risk of this disease. We examined the relationship between anthropometry and physical activity recorded at baseline and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (n = 438,405 males and females age 19-84 years and followed for a total of 2,826,070 person-years). Relative risks (RR) were calculated using Cox proportional hazards models stratified by age, sex, and country and adjusted for smoking and self-reported diabetes and, where appropriate, height. In total, there were 324 incident cases of pancreatic cancer diagnosed in the cohort over an average of 6 years of follow-up. There was evidence that the RR of pancreatic cancer was associated with increased height [RR, 1.74; 95% confidence interval (95% CI), 1.20-2.52] for highest quartile compared with lowest quartile (P(trend) = 0.001). However, this trend was primarily due to a low risk in the lowest quartile, as when this group was excluded, the trend was no longer statistically significant (P = 0.27). A larger waist-to-hip ratio and waist circumference were both associated with an increased risk of developing the disease (RR per 0.1, 1.24; 95% CI, 1.04-1.48; P(trend) = 0.02 and RR per 10 cm, 1.13; 95% CI, 1.01-1.26; P(trend) = 0.03, respectively). There was a nonsignificant increased risk of pancreatic cancer with increasing body mass index (RR, 1.09; 95% CI, 0.95-1.24 per 5 kg/m(2)), and a nonsignificant decreased risk with total physical activity (RR, 0.82; 95% CI, 0.50-1.35 for most active versus inactive). Future studies should consider including measurements of waist and hip circumference, to further investigate the relationship between central adiposity and the risk of pancreatic cancer.


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